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| Status |
Public on May 22, 2024 |
| Title |
Gene expression profile at single nuclei level of cells from mouse hippocampus |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We performed single-nucleus RNA-seq and chromatin accessibility analyses (snRNA-seq and ATAC-seq) in the hippocampus of wild-type (WT) mice and mice carrying amyloid precursor protein knock-in mutations (APPNL-G-F) in response to chronic wheel-running exercise.
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| Overall design |
8-week old female WT and APPNL-G-F mice were put into cages with running wheel for voluntary exercise for 10 weeks. Mice from 4 different conditions (WT_RT, WT_EX, APP_RT, APP_EX) were subjected to single nuclei RNA and ATAC sequencing.
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| |
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| Contributor(s) |
Wenbo L, Li Y, Sun Z |
| Citation(s) |
38746443 |
| |
| Submission date |
Jul 20, 2023 |
| Last update date |
May 23, 2024 |
| Contact name |
Zheng Sun |
| E-mail(s) |
Zheng.Sun@bcm.edu
|
| Organization name |
Baylor College of Medicine
|
| Street address |
1329 Moursund St
|
| City |
Houston |
| State/province |
Texas |
| ZIP/Postal code |
77030 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (4)
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| GSM7655989 |
WT mouse without exercise, hippocampus, snRNAseq |
| GSM7655990 |
WT mouse with exercise, hippocampus, snRNAseq |
| GSM7655991 |
APPNL-G-F mouse without exercise, hippocampus, snRNAseq |
| GSM7655992 |
APPNL-G-F mouse with exercise, hippocampus, snRNAseq |
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| This SubSeries is part of SuperSeries: |
| GSE237925 |
Single-nucleus multi-omics dissection of physical exercise effects on neurocognition |
|
| Relations |
| BioProject |
PRJNA996989 |
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