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| Status |
Public on Jul 01, 2024 |
| Title |
Gene regulation profiling by KMT2D under different glucose conditions in HNSCC (RNAseq) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Histone H3 lysine (H3K4) methyltransferase KMT2D is a key regulator of gene expression, mainly through promoting H3K4 methylation and activating enhancers, and plays critical roles in development, differentiation, metabolism, and tumor suppression. To investigate the mechanisms by which KMT2D loss promotes HNSCC and to identify potential therapeutic targets, we generated KMT2D wild-type (KMT2D-WT) and KMT2D knock-out (KMT2D-KO) SCC23 HNSCC cells and performed RNA-seq under different glucose conditions.
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for KMT2D-WT and KMT2D-KO SCC23 HNSCC cells under high glucose conditions (+Glc) or with glucose deprivation treatment for 6 hours (-Glc).
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| Contributor(s) |
Wang J, Liu W |
| Citation(s) |
39117659 |
| |
| Submission date |
Jul 14, 2023 |
| Last update date |
Aug 30, 2024 |
| Contact name |
Cunyu Wang |
| E-mail(s) |
cunywang@ucla.edu
|
| Phone |
3108256317
|
| Organization name |
university of California, Los Angeles
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| Department |
School of Dentistry
|
| Lab |
CHS 56-200
|
| Street address |
10833 Le Conte Ave
|
| City |
Los Angeles |
| State/province |
CA |
| ZIP/Postal code |
90095 |
| Country |
USA |
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| Platforms (2) |
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| Samples (14)
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| This SubSeries is part of SuperSeries: |
| GSE234716 |
KMT2D regulates gene expression through regulating promoters/enhances upon glucose deprivation. |
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| Relations |
| BioProject |
PRJNA994965 |
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