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Series GSE23743 Query DataSets for GSE23743
Status Public on Sep 10, 2010
Title Effect of imatinib on philadelphia chromosome positive acute lymphoblastic leukemia
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The Philadelphia chromosome (Ph) encodes the oncogenic BCR-ABL1 tyrosine kinase, which defines a subset of acute lymphoblastic leukemia (ALL) with a particularly unfavorable prognosis. In this study, the tyrosine kinase inhibitor imatinib was used for pharmacological inhibition of BCR-ABL1. Gene expression profiles of Ph+ ALL cell lines were analyzed in response to imatinib treatment.
 
Overall design Four Ph+ ALL cell lines (BV-173, NALM-1, SUP-B15, and TOM1) were either treated with 10µM STI571 (Imatinib) for 16 hours or cultured in absence of STI571.
 
Contributor(s) Duy C, Hurtz C, Cerchietti L, Klemm L, Swaminathan S, Shojaee S, Ci W, Geng H, Braig M, Hofmann W, Koeffler PH, Yu JJ, Nahar R, Kweon S, Hennighausen L, Herzog S, Jumaa H, Park E, Kim Y, Groffen J, Heisterkamp N, Ye HB, Melnick AM, Müschen M
Citation(s) 21593872
Submission date Aug 22, 2010
Last update date Dec 06, 2018
Contact name Markus Müschen
E-mail mmuschen@chla.usc.edu
Phone + 1 323 361 5592
Fax +1 323 361 1516
URL http://www.lymphocytes.de/
Organization name University of Southern California
Department Childrens Hospital Los Angeles
Lab Müschen Lab
Street address 4650 Sunset Blvd
City Los Angeles
State/province CA
ZIP/Postal code 90027
Country USA
 
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (8)
GSM577857 BV-173 non-treated
GSM577858 BV-173 Imatinib-treated
GSM577859 NALM-1 non-treated
Relations
BioProject PRJNA130771

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE23743_RAW.tar 14.6 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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