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Series GSE2361 Query DataSets for GSE2361
Status Public on Apr 03, 2005
Title Expression Proflies of Human Normal tissues
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We performed expression profiling of 36 types of normal human tissues and identified 2,503 tissue-specific genes. We then systematically studied the expression of these genes in cancers by re-analyzing a large collection of published DNA microarray datasets. Our study shows that integration of each gene's breadth of expression (BOE) in normal tissues is important for biological interpretation of the expression profiles of cancers in terms of tumor differentiation, cell lineage and metastasis.
Twenty five total RNA specimens were purchased from Clontech (Palo Alto, CA), Ambion (Austin, TX) and Strategene (La Jolla, CA). We tried to cover as many tissue types as possible by using pooled RNA samples. In order to define breadth-of-expression (BOE) accurately at a reasonable cost, we tried to cover as many tissue types as possible by using pooled RNA samples. Each specimen represents a human organ. We used RNA samples pooled from 2 to 84 donors to avoid differences at the individual level.
Keywords = Normal human tissues
Keywords = Tissue-specificity

Detailed sample information and Affymetrix .CEL files are available at http://www.genome.rcast.u-tokyo.ac.jp/normal/

Publication:Ge X et al., Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues.

Genomics. 2005 Aug;86(2):127-141.
PMID: 15950434
Keywords: other
 
Web link http://www.genome.rcast.u-tokyo.ac.jp/normal/
 
Contributor(s) Ge X, Yamamoto S, Tsutsumi S, Midorikawa Y, Ihara S, Wang S, Aburatani H
Citation(s) 15950434
Submission date Mar 04, 2005
Last update date Aug 10, 2018
Contact name Xijin Ge
E-mail xge@enh.org
Phone 1-224-364-7498
URL http://www.genome.rcast.u-tokyo.ac.jp/normal/
Organization name ENH Research Institute
Department Center for Functional Genomics
Street address 1001 University Place
City Evanston
State/province IL
ZIP/Postal code 60201
Country USA
 
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (36)
GSM44671 Normal Heart
GSM44672 Normal Thymus
GSM44673 Normal Spleen
Relations
BioProject PRJNA91209

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE2361_RAW.tar 130.1 Mb (http)(custom) TAR (of CEL, EXP)
Raw data provided as supplementary file

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