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| Status |
Public on Sep 01, 2023 |
| Title |
Preclinical Evidence for the Glucocorticoid-Sparing Potential of a Dual Toll-Like Receptor 7/8 Inhibitor in Autoimmune Diseases |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Single cell RNA-seq analysis of PBMCs testing for a synergistic effect of TLR7/8 inhibition and the glucocorticoid dexamethasone
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| Overall design |
Isolated PBMCs of four healthy human blood donor leukopaks, treated with a TLR7 and/or TLR8 inhibitor and/or dexamethasone
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| Web link |
https://jpet.aspetjournals.org/content/jpet/suppl/2023/09/06/jpet.123.001744.DC1/1744_supp_data.pdf
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| Contributor(s) |
Nicholas G, Andrew B, Evgeni T, Ankita D, Bharat V |
| Citation(s) |
37673681 |
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| Submission date |
Jun 27, 2023 |
| Last update date |
Dec 01, 2023 |
| Contact name |
Andrew Bender |
| E-mail(s) |
andrew.bender@abbvie.com, nicholas.geraci@emdserono.com, carmina.coppola@emdserono.com
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| Organization name |
EMD Serono
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| Department |
Research Unit - Neuroscience & Immunology
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| Lab |
Discovery Biology
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| Street address |
45 Middlesex Turnpike
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| City |
Billerica |
| State/province |
MA |
| ZIP/Postal code |
01821 |
| Country |
USA |
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| Platforms (1) |
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| Samples (24)
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| GSM7512051 |
Donor 1, R848 + MSC 5nm |
| GSM7512052 |
Donor 1, R848 + MSC 15nm |
| GSM7512053 |
Donor 1, R848 + Dex |
| GSM7512054 |
Donor 1, R848 + Dex + MSC 5nm |
| GSM7512055 |
Donor 1, R848 + Dex + MSC 15nm |
| GSM7512056 |
Donor 2, No Treatment |
| GSM7512057 |
Donor 2, Dex only |
| GSM7512058 |
Donor 2, R848 only |
| GSM7512059 |
Donor 2, R848 + MSC 5nm |
| GSM7512060 |
Donor 2, R848 + MSC 15nm |
| GSM7512061 |
Donor 2, R848 + Dex |
| GSM7512062 |
Donor 2, R848 + Dex + MSC 5nm |
| GSM7512063 |
Donor 2, R848 + Dex + MSC 15nm |
| GSM7512064 |
Donor 3, No Treatment |
| GSM7512065 |
Donor 3, Dex only |
| GSM7512066 |
Donor 3, R848 only |
| GSM7512067 |
Donor 3, R848 + MSC 5nm |
| GSM7512068 |
Donor 3, R848 + MSC 15nm |
| GSM7512069 |
Donor 3, R848 + Dex |
| GSM7512070 |
Donor 3, R848 + Dex + MSC 5nm |
| GSM7512071 |
Donor 3, R848 + Dex + MSC 15nm |
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| Relations |
| BioProject |
PRJNA988047 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE235927_steroid.synergy.post-bc.FINALforpublication.RDS.gz |
1019.7 Mb |
(ftp)(http) |
RDS |
| GSE235927_steroid.synergy.post-bc.FINALforpublication.h5ad.gz |
697.5 Mb |
(ftp)(http) |
H5AD |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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