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Series GSE23529 Query DataSets for GSE23529
Status Public on Jun 11, 2012
Title Whole-genome gene expression profiles of non-tumorous human lung tissues: UBC set
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We profiled genome-wide gene expression in non-tumorous human lung tissues. The overall goal of this project is to improve our molecular understanding of various lung diseases including lung cancer and chronic obstructive pulmonary disease (COPD).
Overall design The samples from the University of British Columbia (UBC) were derived from a long-standing tissue bank started by Drs. James C. Hogg and Peter D. Paré (Ding L, Quinlan KB, Elliott WM, Hamodat M, Paré PD, Hogg JC, Hayashi S. A Lung Tissue Bank for Gene Expression Studies in Chronic Obstructive Pulmonary Disease. COPD: Journal of Chronic Obstructive Pulmonary Disease 2004;1:191-204 (PMID 17136987)). Lung specimens were obtained from patients undergoing lung surgery. Primarily this was for resection of benign or malignant lesions. Some were the diseased lungs from transplant recipients. Patients are approached prior to surgery and asked if they would like to donate a portion of the lung tissue that is to be removed for research. It is explained that this would be done after the appropriate diagnostic specimens are taken and that only portions of lung that would be otherwise discarded will be used for research. A small number of lung samples were obtained at the time of autopsy. Immediately after resection, the lobes or lungs were inflated using a 50% mixture of Cryomatrix and saline. The specimens were then frozen in liquid nitrogen fumes and stored at -80C for later RNA extraction. RNAs were extracted and then hybridized to a single custom-made whole-genome human Affymetrix array.
Contributor(s) Hogg JC, Paré PD
Citation(s) 22659451, 25182044, 27995131
Submission date Aug 09, 2010
Last update date Jan 04, 2017
Contact name Yohan Bossé
Organization name Laval University
Street address 2725, chemin Sainte-Foy
City Quebec
State/province Quebec
ZIP/Postal code G1V 4G5
Country Canada
Platforms (1)
GPL10379 Rosetta/Merck Human RSTA Custom Affymetrix 2.0 microarray [HuRSTA-2a520709]
Samples (405)
GSM576670 hLung_UBC_001
GSM576671 hLung_UBC_002
GSM576672 hLung_UBC_003
This SubSeries is part of SuperSeries:
GSE23546 Whole-genome gene expression profiles of non-tumorous human lung tissues
BioProject PRJNA133361

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE23529_RAW.tar 2.0 Gb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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