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Series GSE235146 Query DataSets for GSE235146
Status Public on Dec 06, 2023
Title DNA methylation profiles in human iPSC-derived neurosphere exposed to environmental chemicals
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary Various chemicals, including pesticides, heavy metals, and metabolites of tobacco, have been detected in fetal environment. Fetuses are exposed to these chemicals at relatively low concentrations; however, their risk of developing neurological and behavioral disorders increases after birth. We aimed to evaluate the effects of five chemicals (diethylphosphate, cotinine, octachlorodipropyl ether, mercury, and selenium) detected in the serum of pregnant mothers on DNA methylation status during neural development using human neural stem cells.
 
Overall design Bisulfite converted DNA were hybridised to the Illumina Infunium MethylationEPIC
 
Contributor(s) Arai Y, Nishino K
Citation(s) 37914285
Submission date Jun 16, 2023
Last update date Dec 07, 2023
Contact name Yoshikazu Arai
E-mail(s) ayoshiy55@gmail.com
Organization name University of Miyazaki
Department Faculty of Agriculture
Lab Veterinary Biochemistry and Molecular Biology
Street address Gakuen-Kibahadai-Nishi1-1
City Miyazaki
ZIP/Postal code 8892192
Country Japan
 
Platforms (1)
GPL21145 Infinium MethylationEPIC
Samples (6)
GSM7495940 MRC_NSph_chemicals
GSM7495941 MRC_NSph_solvent
GSM7495942 MRC_NSph_untreated
Relations
BioProject PRJNA984667

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE235146_Matrix_signal_intensities.txt.gz 46.6 Mb (ftp)(http) TXT
GSE235146_RAW.tar 244.7 Mb (http)(custom) TAR (of IDAT)
Processed data included within Sample table

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