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| Status |
Public on Feb 02, 2024 |
| Title |
Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis [scTreg] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We study the effect of Treg cell-derived Areg in chronic liver injury. Here we look at the transcriptional changes of Treg cells in NASH compared to normal chow.
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| Overall design |
Single cell RNA-seq of Treg cells enriched via FACS from the liver, spleen and visceral adipose tissue from Foxp3GFP mice fed normal chow or a NASH diet.
Hashtag 1-3 are normal diet and Hashtag 4-7 are NASH.
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| Contributor(s) |
Arpaia N, Savage TM, Forton KT, de los Santos K, Rouanne M, Oliveras Alsina A, Cavero R, Li F, Haeusler RA, Adam J, Schwabe RF, Shayya HJ, Rae SS |
| Citation(s) |
38309273 |
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| Submission date |
Jun 06, 2023 |
| Last update date |
May 03, 2024 |
| Contact name |
Nicholas Arpaia |
| E-mail(s) |
na2697@cumc.columbia.edu
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| Organization name |
Columbia University
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| Department |
Microbiology & Immunology
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| Street address |
701 West 168th Street
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| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10032 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (9)
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| This SubSeries is part of SuperSeries: |
| GSE208706 |
Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis |
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| Relations |
| BioProject |
PRJNA980619 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE234244_NT016.tar.gz |
26.3 Mb |
(ftp)(http) |
TAR |
| GSE234244_NT017.tar.gz |
25.3 Mb |
(ftp)(http) |
TAR |
| GSE234244_NT018.tar.gz |
16.9 Mb |
(ftp)(http) |
TAR |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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