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| Status |
Public on Feb 02, 2024 |
| Title |
Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis [scHSC] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We study the effect of Treg cell-derived Areg in chronic liver injury. Here we look at the transcriptional changes of hepatic stellate cells in NASH in response to Treg cell-derived Areg.
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| Overall design |
Single cell RNA-seq of hepatic stellate cells enriched via FACS from the liver of AregFl/Fl (control) or AregFl/Fl Foxp3YFP-cre (conditional knockout) mice fed a NASH diet.
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| Contributor(s) |
Arpaia N, Savage TM, Forton KT, de los Santos K, Rouanne M, Oliveras Alsina A, Cavero R, Li F, Haeusler RA, Adam J, Schwabe RF, Shayya HJ, Rae SS |
| Citation(s) |
38309273 |
| |
| Submission date |
Jun 02, 2023 |
| Last update date |
May 03, 2024 |
| Contact name |
Nicholas Arpaia |
| E-mail(s) |
na2697@cumc.columbia.edu
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| Organization name |
Columbia University
|
| Department |
Microbiology & Immunology
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| Street address |
701 West 168th Street
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| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10032 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (2) |
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| This SubSeries is part of SuperSeries: |
| GSE208706 |
Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis |
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| Relations |
| BioProject |
PRJNA979265 |
