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| Status |
Public on Nov 01, 2010 |
| Title |
Loss of sarcolipin results in atrial remodeling |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Sarcolipin (SLN) is a key regulator of SERCA pump in atria. To determine the role of SLN in atrial Ca2+ homeostasis, we have generated a SLN null (sln-/-) mouse model. Ablation of SLN results in increased SR Ca2+ load and Ca2+ transients in atria. Further, loss of SLN results in electrophysiological and strcutural remodeling of atria.
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| Overall design |
The SLN knockout and C57/BL6 wildtype mice (each n=3) were selected for RNA extraction. The cRNA probes were hybridized to Affymetrix gene array.
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| Contributor(s) |
Babu GJ, Mayilvahanan S, Periasamy M, Park JY, Tian B |
| Citation(s) |
22496245 |
| Submission date |
Aug 03, 2010 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Gopal J Babu |
| E-mail(s) |
babugo@umdnj.edu
|
| Phone |
973-972-5376
|
| Fax |
973-972-7489
|
| Organization name |
University of Medicine & Dentistry of New Jersey-NJMS
|
| Department |
CELL BIOLOGY AND MOLECULAR MED
|
| Street address |
185 South Orange Ave
|
| City |
Newark |
| State/province |
NJ |
| ZIP/Postal code |
07101 |
| Country |
USA |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA131051 |
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