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Series GSE23339 Query DataSets for GSE23339
Status Public on May 09, 2011
Title Gene expression profiles of endometriosis
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Endometriosis is a common disease seen by gynecologists. Clinical features involve pelvic pain and unexplained infertility. Although endometriosis is pathologically characterized by endometrial tissue outside the normal uterine location, endometriosis is otherwise not easily explained. Endometriomas, endometriotic cysts of the ovary, typically cause pain and distortion of pelvic anatomy. To begin to understand the pathogenesis of endometriomas, we carried out transcriptome:microRNAome analysis of endometriomas and eutopic endometrium, using gene expression arrays and next generation small RNA sequencing technology.
Keywords: two group comparison
Overall design Patients undergoing surgery for endometriomas, suspected endometriosis, pelvic pain, abnormal uterine bleeding, pelvic organ prolapse, or uterine leiomyomas were approached for participation. After informed consent, the patients underwent scheduled surgical procedure. Tissues were collected either as cyst wall of endometrioma or endometrial curettage of hysterectomy specimen and placed directly into RNALater (Ambion, Austin, TX) and eventually frozen at -80˚C. Samples were designated as endometriomas or non-endometriosis control endometrium based on surgical pathology reports. Total RNA was isolated from frozen tissue. High quality RNA was subjected to Illumina’s Human WG-6 version 2.0 BeadChips (Illumina).
*** This Series represents the transcriptome component of the study. ***
Contributor(s) Creighton C, Matzuk M, Hawkins S
Citation(s) 21436257
Submission date Jul 30, 2010
Last update date Feb 15, 2013
Contact name Chad Creighton
Organization name Baylor College of Medicine
Department Biostatistics, Ducan Cancer Center
Street address One Baylor Plaza, Mail Stop: BCM305
City Houston
State/province TX
ZIP/Postal code 77030
Country USA
Platforms (1)
GPL6102 Illumina human-6 v2.0 expression beadchip
Samples (19)
GSM572747 endometrioma, patient 19
GSM572748 endometrioma, patient 2
GSM572749 endometrioma, patient 6
BioProject PRJNA131475

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE23339_RAW.tar 18.5 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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