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| Status |
Public on Jul 02, 2024 |
| Title |
Multimodal transcriptomics reveal neurogenic aging trajectories and age-related regional inflammation in the dentate gyrus |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
Other
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| Summary |
Single-cell RNA sequencing was performed on dentate gyrus of C57Bl/6 mice at ages ranging from 3 MO to 21 MO. Spatial transcriptomics was performed on whole brain sections from cage littermates
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| Overall design |
34732 single cells isolated from the dentate gyrus of mice for scRNA-seq. 42169 spots were profiled on the brain coronal sections.
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| Web link |
http://DOI: 10.1038/s41593-024-01848-4
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| Contributor(s) |
Wu Y, Llorens-Bobadilla E, Frisen J, Jessberger S |
| Citation(s) |
39762661 |
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| Submission date |
May 24, 2023 |
| Last update date |
Feb 05, 2025 |
| Contact name |
Yicheng Wu |
| E-mail(s) |
yicheng.wu1987@gmail.com
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| Organization name |
University of Pennsylvania
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| Department |
Neuroscience
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| Street address |
415 Curie Boulevard
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| City |
Philadelphia |
| State/province |
Pennsylvania |
| ZIP/Postal code |
19104 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (20)
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| GSM7426319 |
Old, 2, scRNAseq |
| GSM7426320 |
Young, 1, spatial transcriptomics |
| GSM7426321 |
Young, 2, spatial transcriptomics |
| GSM7426322 |
Young, 3, spatial transcriptomics |
| GSM7426323 |
Young, 4, spatial transcriptomics |
| GSM7426324 |
Middle-age, 1, spatial transcriptomics |
| GSM7426325 |
Middle-age, 2, spatial transcriptomics |
| GSM7426326 |
Middle-age, 3, spatial transcriptomics |
| GSM7426327 |
Middle-age, 4, spatial transcriptomics |
| GSM7426328 |
Old, 1, spatial transcriptomics |
| GSM7426329 |
Old, 2, spatial transcriptomics |
| GSM7426330 |
Old, 3, spatial transcriptomics |
| GSM7426331 |
Old, 4, spatial transcriptomics |
| GSM7426332 |
Old, 5, spatial transcriptomics |
| GSM7426333 |
Old, 6, spatial transcriptomics |
| GSM7426334 |
Old, 7, spatial transcriptomics |
| GSM7426335 |
Old, 8, spatial transcriptomics |
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| Relations |
| BioProject |
PRJNA975913 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE233363_RAW.tar |
1.0 Gb |
(http)(custom) |
TAR (of MTX, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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