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| Status |
Public on Apr 10, 2024 |
| Title |
Pyroptotic T-cell-derived active IL-16 has a driving function in endometriosis development |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Endometriosis is a common, chronic inflammatory condition that frequently results in pain and infertility and is estimated to affect 6–10% of women of reproductive age. However, the mechanisms underlying the induction of inflammation in endometriosis remain unclear. Here, we identified that ectopic endometrial T-cell-derived active interleukin (IL)-16 acts as an inflammation-driving cytokine in endometriosis. Furthermore, we found that in ectopic endometrial T cells, the activation of IL-16 requires iron overload-induced caspase-3 activity and that the release of active IL-16 is reliant on GSDME-mediated pyroptosis. These observations suggest that active IL-16 may represent a promising target in the treatment of endometriosis.
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| Overall design |
In this dataset contains 1 cases of transcriptome information from 3 normal endometrial tissue of patients with uterine leiomyoma (NE_1), 1 cases from ectopic endometrial tissue samples of patients with endometriosis (EE).
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| Contributor(s) |
Zhang J, Wei H |
| Citation(s) |
38508138 |
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| Submission date |
Apr 14, 2023 |
| Last update date |
Apr 11, 2024 |
| Contact name |
Jinghe Zhang |
| E-mail(s) |
zjh0613@mail.ustc.edu.cn
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| Organization name |
University of Science and Technology of China
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| Street address |
Huangshan Road 443
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| City |
Hefei |
| State/province |
Anhui |
| ZIP/Postal code |
230027 |
| Country |
China |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA955729 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE229735_RAW.tar |
70.0 Mb |
(http)(custom) |
TAR (of MTX, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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