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| Status |
Public on Apr 08, 2024 |
| Title |
Tonic type 2 immunity controls autoimmunity in the skin |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The existence of immunoregulatory mechanisms that control autoimmunity in non-lymphoid tissues remains unclear. Through transcriptomic and lipidomic analyses, we found that psoriasis is tightly associated with a significant downregulation of fatty acid metabolism and biosynthesis pathways as well as Th2 signature genes. Among lipids-activated transcription factors, LXR and PPAR were required for fatty acid homeostasis and resistance to psoriasis in mice. STAT6 played a role in the homeostatic expression of LXR and PPARγ in the skin. Additionally, innate lymphoid cells established tonic type 2 immunity in normal skin by producing IL-13 continually. Mice lacking tonic type 2 immunity were more susceptible to psoriatic inflammation in vivo. In human skin, inhibiting tonic type 2 immunity worsened psoriasis-like inflammation and IL-17 production, while activating LXR or PPAR inhibited them. Therefore, tonic type 2 immunity is an essential tissue checkpoint that represses autoimmunity and maintains lipid homeostasis in the skin.
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for ear skins with chemical treatments (GW3965 or Troglitazone).
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| Web link |
https://www.sciencedirect.com/science/article/pii/S2211124724006922?via%3Dihub
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| Contributor(s) |
Chung Y |
| Citation(s) |
38900635 |
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| Submission date |
Apr 07, 2023 |
| Last update date |
Jul 08, 2024 |
| Contact name |
Haeseung Lee |
| E-mail(s) |
haeseung@pusan.ac.kr
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| Organization name |
Pusan National University
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| Department |
College of Pharmacy
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| Street address |
63 Beon-gil 2, Busandaehag-ro, Geumjeong-gu
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| City |
Busan |
| ZIP/Postal code |
46241 |
| Country |
South Korea |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (12)
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| GSM7156603 |
IMQ/Veh, Day 6, rep1 |
| GSM7156604 |
IMQ/Veh, Day 6, rep2 |
| GSM7156605 |
IMQ/Veh, Day 6, rep3 |
| GSM7156606 |
IMQ/GW3965, Day 6, rep1 |
| GSM7156607 |
IMQ/GW3965, Day 6, rep2 |
| GSM7156608 |
IMQ/GW3965, Day 6, rep3 |
| GSM7156609 |
IMQ/Troglitazone, Day 6, rep1 |
| GSM7156610 |
IMQ/Troglitazone, Day 6, rep2 |
| GSM7156611 |
IMQ/Troglitazone, Day 6, rep3 |
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| Relations |
| BioProject |
PRJNA953394 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE229198_RAW.tar |
13.8 Mb |
(http)(custom) |
TAR (of RESULTS) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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