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| Status |
Public on Jul 05, 2024 |
| Title |
Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To investigate BRN1/2 function in neocortical development, we knockout BRN1/2 in the dorsal telencephalon (BRN1/2 cKO)
We then performed gene expression profiling analysis using data obtained from scRNA-seq of 13 different mice at E12.5 and E14.5
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| |
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for BRN1/2 cKO and control littermates at E12.5 and E14.5
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| Web link |
https://doi.org/10.1038%2Fs41467-024-52443-x
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| |
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| Contributor(s) |
Barao S, Xu Y, Llongueras JP, Vistein R, Goff L, Nielsen K, Bae B, Smith RS, Walsh CA, Stein-O'Brien G, Mueller U |
| Citation(s) |
39271675 |
| |
| Submission date |
Apr 06, 2023 |
| Last update date |
Oct 06, 2024 |
| Contact name |
Soraia Barao |
| Organization name |
JHU
|
| Department |
Neuroscience
|
| Lab |
Mueller
|
| Street address |
725 N Wolfe St PCTB 1015
|
| City |
Baltimore |
| State/province |
MD |
| ZIP/Postal code |
21205 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (13)
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| Relations |
| BioProject |
PRJNA953007 |
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