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| Status |
Public on Mar 31, 2024 |
| Title |
Human Cortical Kidney Sections |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Other
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| Summary |
Acute kidney injury (AKI) is a major health burden in the United States. Macrophages have been shown to mediate AKI in murine models. Murine kidneys contain multiple subpopulations of kidney resident macrophages (KRM) that are transcriptionally and spatially distinct. We hypothesized the human kidney contains orthologous KRM subpopulations, both transcriptionally and spatially. We utilized kidney sections from donors diagnosed with mild to moderate AKI in order to increase the translatability of murine research to clinical settings.
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| Overall design |
Visium samples include 10 micron sections of human kidneys.
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| Contributor(s) |
Erman EN, Moore KH, Cheung MD, La Fontaine JR, Yang Z, Soliman R, Aqarwal A, George JF |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Mar 24, 2023 |
| Last update date |
Apr 01, 2024 |
| Contact name |
James F George |
| E-mail(s) |
jfgeorge@uabmc.edu
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| Phone |
2059344261
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| Organization name |
University of Alabama at Birmingham
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| Street address |
1720 2nd Ave South
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| City |
Birmingham |
| State/province |
Alabama |
| ZIP/Postal code |
35294 |
| Country |
USA |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA948424 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE228169_RAW.tar |
66.4 Mb |
(http)(custom) |
TAR (of CSV, JPG, JSON, MTX, PNG, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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