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Series GSE228100 Query DataSets for GSE228100
Status Public on Nov 15, 2023
Title LOGGIC Core BioClinical Data Bank: Added clinical value of RNA-Seq in an international molecular diagnostic registry for pediatric low-grade glioma patients
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary We compared gene panel sequencing and DNA methylation analysis with RNA sequencing results from 125 patients. We could demonstrate improvement of diagnostic accuracy and clinical patient benefit by the addition of RNA sequencing fom fresh frozen tumor tissue.
 
Overall design 125 pLGG tumors were profiled on IlluminaHumanMethylation 850k arrays.
 
Contributor(s) Hardin EC, Schmid S, Sommerkamp A, Bodden C, Heipertz A, Sievers P, Wittmann A, Milde T, Pfister SM, von Deimling A, Horn S, Herz NA, Simon M, Perera AA, Azizi A, Cruz O, Curry S, Van Damme A, Garami M, Hargrave D, Kattamis A, Faganel Kotnik B, Lähteenmäki P, Scheinemann K, Schouten-van Meeteren AY, Sehested A, Viscardi E, Wormdal OM, Zapotocky M, Ziegler D, Koch A, Hernáiz Driever P, Witt O, Capper D, Sahm F, Jones DT, van Tilburg CM
Citation(s) 37075810
Submission date Mar 23, 2023
Last update date Nov 16, 2023
Contact name Martin Sill
E-mail(s) m.sill@dkfz.de
Organization name DKFZ
Department Division of Pediatric Neurooncology
Street address Im Neuenheimer Feld 280
City Heidelberg
ZIP/Postal code 69120
Country Germany
 
Platforms (1)
GPL21145 Infinium MethylationEPIC
Samples (124)
GSM7113900 CNS-tumor_pediatric-LGG_64407
GSM7113901 CNS-tumor_pediatric-LGG_11409
GSM7113902 CNS-tumor_pediatric-LGG_74701
Relations
BioProject PRJNA948038

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE228100_RAW.tar 1.9 Gb (http)(custom) TAR (of IDAT)
GSE228100_betas_preprocessed.txt.gz 424.8 Mb (ftp)(http) TXT
Processed data are available on Series record
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