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| Status |
Public on Sep 11, 2023 |
| Title |
Mechanisms of endothelial injury and transplant-associated thrombotic microangiopathy in tandem autologous hematopoietic stem cell transplant for neuroblastoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Our data indicate that endothelial injury is increased in auto-stem cell transplant patients receiving the specific conditioning regimen carboplatin, etoposide and melphalan and is associated with clinical TA-TMA. Moreover, our data identify specific pathways that can be targeted to treat or prevent TA-TMA.
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| Overall design |
RNAseq was performed on glomerular endothelial cells cultured with serum from neuroblastoma patients who developed TA-TMA (n=5), timepoint-matched serum from neuroblastoma patients who did not develop TA-TMA (n=4) and complete media alone (no human serum, n=1).
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| Contributor(s) |
Sabulski A, Abdullah S, Luebbering N, Aunins B, Jodele S, Davies SM |
| Citation(s) |
37317894 |
| |
| Submission date |
Mar 12, 2023 |
| Last update date |
Dec 12, 2023 |
| Contact name |
Stella Davies |
| E-mail(s) |
Stella.Davies@cchmc.org
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| Organization name |
Cincinnati Children's Hospital
|
| Department |
Cancer & Blood Disease Institute
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| Lab |
Davies
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| Street address |
3333 Burnet Ave
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| City |
Cincinnati |
| State/province |
OH |
| ZIP/Postal code |
45229 |
| Country |
USA |
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| Platforms (1) |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA943507 |
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