Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing
Summary
NK cells engineered to express IL-21 (IL-21 NK) acquire strong antitumor activity, with the ability to respond to glioblastoma (GBM) rechallenge in vitro and in vivo. IL-21 NK cells have a unique signature of chromatin accessibility, with CCAAT/Enhancer-Binding Protein (C/EBP), especially CEBPD, serving as key transcription factors regulating their memory response.
Overall design
The objective of this study was to investigate the epigenetic factors that contributing for memory formation in NK cells
Less...
More...