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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Sep 14, 2023 |
| Title |
A Cellular Atlas of the Down Syndrome Brain Identifies Accelerated Oligodendrocyte Precursor Cell Senescence |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
We performed single nucleus RNA-seq and single nucleus ATAC-seq on the cortex of Ts65Dn mouse model of Down Syndrome and euploid controls (wild types).
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| Overall design |
Single nucleus RNA-seq and ATAC seq from 6 month old mouse cortex under two conditions: 1)Control (wild type), 2)Ts65Dn mouse model for Down Syndrome.
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| Contributor(s) |
Kalish B |
| Citation(s) |
37491366 |
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| Submission date |
Feb 17, 2023 |
| Last update date |
Sep 15, 2023 |
| Contact name |
Brian Kalish |
| E-mail(s) |
brian.kalish@childrens.harvard.edu
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| Phone |
4164275557
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| Organization name |
Boston Children's Hospital
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| Department |
Neurobiology
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| Lab |
Kalish
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| Street address |
220 Longwood Ave
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| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02115 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (12)
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| GSM7050275 |
6 month old control mice, biological rep1 (snRNA-seq) |
| GSM7050276 |
6 month old control mice, biological rep 2 (snRNA-seq) |
| GSM7050277 |
6 month old control mice, biological rep 3 (snRNA-seq) |
| GSM7050278 |
6 month old Ts65Dn mouse model for down syndrome, biological rep1 (snRNA-seq) |
| GSM7050279 |
6 month old Ts65Dn mouse model for down syndrome, biological rep 2 (snRNA-seq) |
| GSM7050280 |
6 month old Ts65Dn mouse model for down syndrome, biological rep 3 (snRNA-seq) |
| GSM7050281 |
6 month old control mice, biological rep1 (snATAC-seq) |
| GSM7050282 |
6 month old control mice, biological rep 2 (snATAC-seq) |
| GSM7050283 |
6 month old control mice, biological rep 3 (snATAC-seq) |
| GSM7050284 |
6 month old Ts65Dn mouse model for down syndrome, biological rep1 (snATAC-seq) |
| GSM7050285 |
6 month old Ts65Dn mouse model for down syndrome, biological rep 2 (snATAC-seq) |
| GSM7050286 |
6 month old Ts65Dn mouse model for down syndrome, biological rep 3 (snATAC-seq) |
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| Relations |
| BioProject |
PRJNA936175 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE225554_RAW.tar |
14.6 Gb |
(http)(custom) |
TAR (of H5, MTX, TBI, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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