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| Status |
Public on Sep 11, 2023 |
| Title |
Cross-species single-cell transcriptomic analysis reveals the landscape of animal gastric antrum [scRNA-Seq] |
| Organisms |
Homo sapiens; Sus scrofa; Mus musculus; Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Purpose: To reveal the consistency and difference of gastric antrum epithelial cells among species and provides insights into the selection of model organisms in different research directions in the future.
Methods:In this study, we collected antrum epithelial tissues from human, pig, rat and mouse for scRNA-seq and conducted cross species analysis.
Results: In pig antral epithelium, we identify a novel cell cluster. We also discovered that the porcine antral epithelium owns stronger immune function than the other species. Further analysis reveals this may be due to the insufficient function of porcine immune cells.
Conclusions:Our results replenish the information of multiple species of gastric antral epithelium at the single cell level, providing data resources for understanding the basic situation of gastric antrum epithelial cells.
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| Overall design |
Single cell profiles of gastric antrum epithelial cells from human, pig, rat and mouse
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| |
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| Contributor(s) |
Chen Y, Wang X, Hong F, Li H, Liu Y, Wang Y, Zhang M, Lin S, Liang H |
| Citation(s) |
37525021 |
| |
| Submission date |
Feb 14, 2023 |
| Last update date |
Sep 11, 2023 |
| Contact name |
Ye-guang Chen |
| E-mail(s) |
ygchen@mail.tsinghua.edu.cn
|
| Organization name |
Tsinghua University
|
| Department |
School of life science
|
| Lab |
Molcell
|
| Street address |
Tsinghua Road, Medical Building
|
| City |
Beijing |
| ZIP/Postal code |
100084 |
| Country |
China |
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| Platforms (4)
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| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
| GPL25947 |
Illumina NovaSeq 6000 (Rattus norvegicus) |
| GPL26351 |
Illumina NovaSeq 6000 (Sus scrofa) |
|
| Samples (7)
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| This SubSeries is part of SuperSeries: |
| GSE225276 |
Cross-species single-cell transcriptomic analysis reveals the landscape of animal gastric antrum |
|
| Relations |
| BioProject |
PRJNA934888 |
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