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Series GSE223781 Query DataSets for GSE223781
Status Public on Nov 02, 2023
Title Transcriptional dysregulation impairs efficacy of neural stem cell activation during aging.
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary To study the role of MLL complex in transcriptional dysregulation of NSC aging, we performed ChIP-seq of MLL complex subunits (Kmt2d, Rbbp5, and Wdr5) and Cbx3 in young and aged NSCs to analyze their binding activity at promoters of age-dependent genes.
 
Overall design Primary NSCs were isolated from the subventricular zone of the lateral ventricles (SVZ) in the brains of young and aged mice, respectively. The NSCs were maintained in the initial proliferation medium and used in ChIP-sequencing analysis.
 
Contributor(s) Li M, Huang C
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Submission date Jan 26, 2023
Last update date Nov 02, 2023
Contact name Chengyang Peter Huang
E-mail(s) chengyhuang@hotmail.com
Organization name Shantou University Medical College
Street address 22 Xinling Street
City Shantou
ZIP/Postal code 515041
Country China
 
Platforms (2)
GPL19057 Illumina NextSeq 500 (Mus musculus)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (24)
GSM6995261 Kmt2d_Young_Rep1
GSM6995262 Kmt2d_Aged_Rep1
GSM6995263 Rbbp5_Young_Rep1
This SubSeries is part of SuperSeries:
GSE212725 Transcriptional and epigenetic dysregulation impairs generation of proliferative neural stem and progenitor cells during brain aging
Relations
BioProject PRJNA928369

Download family Format
SOFT formatted family file(s) SOFTHelp
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Supplementary file Size Download File type/resource
GSE223781_Aged_Cbx3_peaks.bedGraph.gz 680.7 Mb (ftp)(http) BEDGRAPH
GSE223781_Aged_Kmt2d_peaks.bedGraph.gz 234.8 Mb (ftp)(http) BEDGRAPH
GSE223781_Aged_Rbbp5_peaks.bedGraph.gz 325.2 Mb (ftp)(http) BEDGRAPH
GSE223781_Aged_Wdr5_peaks.bedGraph.gz 399.4 Mb (ftp)(http) BEDGRAPH
GSE223781_Young_Cbx3_peaks.bedGraph.gz 786.5 Mb (ftp)(http) BEDGRAPH
GSE223781_Young_Kmt2d_peaks.bedGraph.gz 350.4 Mb (ftp)(http) BEDGRAPH
GSE223781_Young_Rbbp5_peaks.bedGraph.gz 297.8 Mb (ftp)(http) BEDGRAPH
GSE223781_Young_Wdr5_peaks.bedGraph.gz 389.5 Mb (ftp)(http) BEDGRAPH
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Processed data are available on Series record

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