|
| Status |
Public on Feb 10, 2023 |
| Title |
The regulative role of DAXX in the gene expression in C9HRE ALS/FTD patient motor neurons |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To investigate the role of DAXX in the C9HRE-associated gene dysregulation inALS/FTD patient-derived motor neurons.
|
| |
|
| Overall design |
Two pairs of C9HRE ALS/FTD patient iPSCs and their isogenic controls, in which the C9Orf72 HRE mutation was removed, were differentiated into motor neurons. RNA-seq was employed to profile the global gene expression in the isogenic iMNs, C9HRE iMNs, and the C9HRE iMNs treated with shRNA targeting DAXX.
|
| |
|
| Contributor(s) |
Liu Y, Wang J |
| Citation(s) |
36822200 |
| |
| Submission date |
Jan 23, 2023 |
| Last update date |
May 12, 2023 |
| Contact name |
Yang Liu |
| E-mail(s) |
liuyang19870210@outlook.com
|
| Organization name |
Johns Hopkins University
|
| Department |
Biochemistry and Molecular Biology
|
| Lab |
Wang Lab
|
| Street address |
615 N. Wolfe Street
|
| City |
Baltimore |
| State/province |
MD |
| ZIP/Postal code |
21211 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (6)
|
|
| This SubSeries is part of SuperSeries: |
| GSE223259 |
Chromatin accessibilities in C9HRE ALS/FTD patient cells |
|
| Relations |
| BioProject |
PRJNA926611 |
Less...
More...