|
| Status |
Public on Jul 08, 2011 |
| Title |
Gene expression profiling of early primary breast cancer to identify prognostic markers and associated pathways |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Retrospective series of primary breast cancer patients who received surgery between 1989 and 1992. Patients received adjuvant chemotherapy and/or adjuvant hormone therapy, or no adjuvant treatment. Tamoxifen was used as endocrine therapy for 5 years in ER+ BC patients. Patients who were <50 years of age, with lymph node positive tumors, or ER– and/or >3 cm in diameter, received adjuvant cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) for six cycles, in a thrice weekly intravenous regimen. Patients >50 years of age with ER–, lymph node–positive tumors also received CMF.
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| |
|
| Overall design |
Retrospective clinical study to identify breast cancer prognostic markers and associated pathways. 216 early primary breast cancers were considered who had complete 10-years follow-up, clinical and demographics information.
mRNA profiling data.
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| |
|
| Contributor(s) |
Buffa FM, Winchester L |
| Citation(s) |
21737487 |
| |
| Submission date |
Jun 08, 2010 |
| Last update date |
Jan 29, 2013 |
| Contact name |
Francesca Buffa |
| E-mail(s) |
francesca.buffa@imm.ox.ac.uk
|
| Organization name |
University of Oxford
|
| Street address |
The Weatherall Institute of Molecular Medicine
|
| City |
Oxford |
| ZIP/Postal code |
OX3 9DS |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL6098 |
Illumina humanRef-8 v1.0 expression beadchip |
|
| Samples (216)
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| This SubSeries is part of SuperSeries: |
| GSE22220 |
Analysis of early primary breast cancer to identify prognostic markers and associated pathways: mRNA and miRNA profiling |
|
| Relations |
| BioProject |
PRJNA129185 |
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