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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Dec 22, 2010 |
| Title |
Expression profiles of the hippocampus of Rsk2-KO mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Coffin–Lowry Syndrome (CLS) is a syndromic form of mental retardation caused by loss of function mutations in the X-linked RPS6KA3 gene, which encodes Rsk2, a serine/threonine kinase involved in spatial memory. We analyzed hippocampal gene expression profiles in Rsk2-KO mice to identify changes in molecular pathways.
Total RNA was extracted from hippocampi from 6 KO and 6 WT (littermates) 2-month-old male mice. For each genotype, equivalent amounts of RNA from 2 mice were pooled and processed for hybridization to the genome wide oligonucleotide microarray (Murine 430A 2.0 Affymetrix, 22.000 probe sets). Thus, 3 independent pooled samples were hybridized for each genotype.
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| Overall design |
We compared hippocampal gene expression profiles from rsk2-KO and normal littermate mice to identify changes in molecular pathways
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| Contributor(s) |
Mehmood T, Schneider A, Sibillec J, Marques-Pereira P, Pannetier S, Ammar M, Dembele D, Thibault-Carpentier C, Rouach N, Hanauer A |
| Citation(s) |
21116650 |
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| Submission date |
Jun 04, 2010 |
| Last update date |
May 04, 2018 |
| Contact name |
André Hanauer |
| E-mail(s) |
andre@igbmc.fr
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| Phone |
33-388653400
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| Fax |
33-388653246
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| Organization name |
IGBMC
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| Department |
Neurobiology and Genetics
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| Street address |
1, rue laurent Fries
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| City |
Illkirch |
| ZIP/Postal code |
67404 |
| Country |
France |
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| Platforms (1) |
| GPL8321 |
[Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA127575 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE22137_RAW.tar |
49.9 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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