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| Status |
Public on Mar 05, 2024 |
| Title |
Spatial Multi-omics Reveals the Heterogeneity of Tumor Microenvironment in the OSF-Associated OSCC |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Other
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| Summary |
Oral submucous fibrosis (OSF) is one of the most common precancerous malignant orders (PMO) with high rates exacerbating into oral squamous cell carcinoma (OSCC), mostly occurred in patients with chewing betel-nut habits in Southeast Asia and Pacific region. However, the spatial characteristics and heteogeneities of tumor microenvironment (TME) in OSF-associated OSCC still remains unclear. Here, we characterized the spatiotemporal changes of OSF-associated OSCC at different malignant states by performing 10x Visium Spatial Transcriptomics (ST) sequencing and airflow-assisted desorption electrospray ionization-mass spectrometry imaging (AFADESI-MSI) analysis.
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| Overall design |
Samples from 4 OSF-associated OSCC patients were analysed by Spatial Transcriptomics sequencing (ST) and airflow-assisted desorption electrospray ionization-mass spectrometry imaging (AFADESI-MSI)
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| Contributor(s) |
Xiong W, Zeng Z |
| Citation(s) |
38229179 |
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| Submission date |
Dec 14, 2022 |
| Last update date |
Mar 06, 2024 |
| Contact name |
Wei Xiong |
| E-mail(s) |
xiongwei@csu.edu.cn
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| Organization name |
Central South University
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| Department |
Cancer Research Institute
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| Street address |
110 Xiangya Road
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| City |
Changsha |
| State/province |
Hunan |
| ZIP/Postal code |
410078 |
| Country |
China |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA912193 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE220978_RAW.tar |
260.2 Mb |
(http)(custom) |
TAR (of MTX, TAR, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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