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Series GSE218716 Query DataSets for GSE218716
Status Public on Mar 06, 2024
Title EZH2 gain-of-function mutations distort  H3K27me3 landscapes and transform transcriptional responses to PRC2 inhibition [ChIP-Seq/Cut&Run-Seq]
Organisms Homo sapiens; Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Other
Summary We have modelled several tumor-associated PRC2 mutations in a single isogenic system in order to reveal their comparative impacts on chromatin and transcription.
We have also explored the link between EZH2 mutational status and abnormal H3K27 methylation in a unique longitudinal cohort of follicular lymphoma (FL) patient samples.
 
Overall design Differential analyses assessing the impact of PRC2 mutations on H3K27me3 genome-wide binding patterns in MEFs and follicular lymphoma samples.
 
Contributor(s) Romero P, Richart L, Wassef M, Holoch D, Margueron R
Citation(s) 38658543
Submission date Nov 25, 2022
Last update date May 17, 2024
Contact name Laia Richart
E-mail(s) laia.richart-gines@curie.fr, laia.richart1986@gmail.com
Organization name Institut Curie
Department Developmental Biology
Lab Mechanisms of Repression by Polycomb Proteins
Street address 13 Rue Pierre et Marie Curie
City Paris
ZIP/Postal code 75005
Country France
 
Platforms (2)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (156)
GSM6755489 PRC2 WT iMEFs H2AUb rep1 [D387C101]
GSM6755490 PRC2 WT iMEFs H2AUb rep2 [D387C102]
GSM6755491 Ezh2_KO iMEFs H2AUb rep1 [D387C103]
This SubSeries is part of SuperSeries:
GSE218717 EZH2 gain-of-function mutations distort  H3K27me3 landscapes and transform transcriptional responses to PRC2 inhibition.
Relations
BioProject PRJNA905336

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE218716_H3K27Ac_EED.KO_macs2_peaks.merged.bed.gz 317.8 Kb (ftp)(http) BED
GSE218716_H3K27Ac_EZH2.KO_macs2_peaks.merged.bed.gz 271.1 Kb (ftp)(http) BED
GSE218716_H3K27Ac_H3K27M_macs2_peaks.merged.bed.gz 289.7 Kb (ftp)(http) BED
GSE218716_H3K27Ac_WT_macs2_peaks.merged.bed.gz 270.5 Kb (ftp)(http) BED
GSE218716_H3K27Ac_Y641F_macs2_peaks.merged.bed.gz 260.1 Kb (ftp)(http) BED
GSE218716_H3K27Ac_all.FL_macs2_peaks.bed.gz 233.1 Kb (ftp)(http) BED
GSE218716_H3K27me2_WT_csaw_regions.bed.gz 91.6 Kb (ftp)(http) BED
GSE218716_H3K27me3_H3K27M_macs2_peaks.merged.bed.gz 81.2 Kb (ftp)(http) BED
GSE218716_H3K27me3_WT.EZH2i.0.125_macs2_peaks.merged.bed.gz 62.1 Kb (ftp)(http) BED
GSE218716_H3K27me3_WT.EZH2i.0.250_macs2_peaks.merged.bed.gz 44.5 Kb (ftp)(http) BED
GSE218716_H3K27me3_WT.ctrl_macs2_peaks.merged.bed.gz 185.5 Kb (ftp)(http) BED
GSE218716_H3K27me3_WT_macs2_peaks.merged.bed.gz 202.5 Kb (ftp)(http) BED
GSE218716_H3K27me3_Y641F.EZH2i.0.125_macs2_peaks.merged.bed.gz 154.2 Kb (ftp)(http) BED
GSE218716_H3K27me3_Y641F.EZH2i.0.250_macs2_peaks.merged.bed.gz 127.6 Kb (ftp)(http) BED
GSE218716_H3K27me3_Y641F.ctrl_macs2_peaks.merged.bed.gz 174.0 Kb (ftp)(http) BED
GSE218716_H3K27me3_all.FL_csaw_regions.bed.gz 136.6 Kb (ftp)(http) BED
GSE218716_RAW.tar 14.5 Gb (http)(custom) TAR (of BW)
GSE218716_Suz12_WT_macs2_peaks.merged.bed.gz 24.4 Kb (ftp)(http) BED
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Raw data are available in SRA
Processed data provided as supplementary file
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