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| Status |
Public on Sep 12, 2011 |
| Title |
Transcriptome of the Nxnl2-/- mouse retina |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
A nxnl2 knockout mouse model was created and the transcriptome used to demonstrate that the retina is compromised by the absence of nxnl2.
For the mouse lacking Nxnl2, the gene encoding RdCVF2, the progressive decline of the visual performance of the cones in parallel with their degeneration arises due to loss of trophic support from RdCVF2
Keywords: genetic modification, transcription-profile, retina
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| Overall design |
In total 6 samples were analyzed, they represent the genotypes wt/wt and ko/ko that were tested in triplicate each.
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| Contributor(s) |
Jaillard C, Mouret A, Niepon M, Irene L, Emanuelle C, Aït-Ali N, Millet-Puel G, Sedmak T, Yang Y, Raffelsberger W, Kinzel B, Trembleau A, Poch O, Bennett J, Wolfrum U, Lledo M, Sahel J, Leveillard T |
| Citation(s) |
22343139 |
| Submission date |
May 17, 2010 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Wolfgang Raffelsberger |
| E-mail(s) |
w.raffelsberger@unistra.fr
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| Organization name |
IGBMC
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| Department |
DBGS
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| Lab |
LBGI
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| Street address |
1 rue Laurent Fries
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| City |
Illkirch/Strasbourg |
| ZIP/Postal code |
67404 |
| Country |
France |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA127047 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE21863_RAW.tar |
35.6 Mb |
(http)(custom) |
TAR (of CEL) |
| Raw data provided as supplementary file |
| Processed data included within Sample table |
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