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| Status |
Public on Oct 31, 2024 |
| Title |
The deubiquitinase OTUD1 attenuates periodontal inflammation by restricting neutrophil protein transport |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We report that OTUD1 acts as an immune regulator in periodontitis. OTUD1 inhibits neutrophils migration to inflammatory site via blocking surface protein presentation. Our data reveals that activation of OTUD1 may be a potential strategy for periodontitis treatment.
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| Overall design |
Study of gingiva infiltration immune cells from WT or Otud1-/- mice in the context of experimental periodontitis using 10x scRNA-seq technologies.
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| Contributor(s) |
Song J, Zhang X, Lu D |
| Citation missing |
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| |
| Submission date |
Oct 25, 2022 |
| Last update date |
Oct 31, 2024 |
| Contact name |
Jia Song |
| E-mail(s) |
songjia@bjmu.edu.cn
|
| Phone |
+18830053918
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| Organization name |
Peking University
|
| Street address |
Peking University School of Medicine, 38 Xueyuan Road, Haidian District, Beijing
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| City |
Beijing |
| State/province |
China |
| ZIP/Postal code |
100080 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA894293 |
