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| Status |
Public on Jan 04, 2023 |
| Title |
Three-dimensional analysis of genome organization in CTCF-WT and CTCF-KO dendritic cells (RNA-Seq II) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Purpose: The goals of this study are to analyze global transcriptional, epigenetic and topological changes in dendritic cells under LPS treatment condition and to investigate how CTCF regulates three-dimensional chromatin interaction in inflammatory response.
Conclusions: Our study provides the detailed analysis of transcriptional, epigenetic and topological genome profiles in mouse dendritic cells under LPS treatment condition. Moreover, our data show how three-dimensional enhancer networks control gene expression during DC activation.
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| |
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| Overall design |
NF-κB inhibitor (JSH23) and LPS treated RNA profiles of CTCF-WT cells with biological replicates.
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| |
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| Contributor(s) |
Yang B, Kim K |
| Citation(s) |
36882470 |
| |
| Submission date |
Oct 07, 2022 |
| Last update date |
Mar 14, 2023 |
| Contact name |
Hyoung-Pyo Kim |
| E-mail(s) |
kimhp@yuhs.ac
|
| Organization name |
Yonsei University College of Medicine
|
| Department |
Department of Tropical Medicine
|
| Street address |
Yonsei-ro 50-1
|
| City |
Seoul |
| ZIP/Postal code |
03722 |
| Country |
South Korea |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
|
| Samples (12)
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| This SubSeries is part of SuperSeries: |
| GSE185884 |
Three-dimensional analysis of genome organization in CTCF-WT and CTCF-KO dendritic cells |
|
| Relations |
| BioProject |
PRJNA888209 |
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