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| Status |
Public on Nov 02, 2023 |
| Title |
Transcriptional dysregulation impairs efficacy of neural stem cell activation during aging [ATAC-seq] |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
To examine whether chromatin accessibility is associated with transcription of age-dependent genes in NSC aging, we profiled the chromatin accessibility at the promoters and enhancers of age-dependent genes using the assay for transposase-accessible chromatin with sequencing (ATAC-seq).
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| Overall design |
Primary NSCs were isolated from the subventricular zone of the lateral ventricles (SVZ) in the brains of young and aged mice, respectively. The NSCs were maintained in the initial proliferation medium and used in ATAC-Seq analysis.
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| Contributor(s) |
Li M, Huang C |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Oct 06, 2022 |
| Last update date |
Nov 02, 2023 |
| Contact name |
Chengyang Peter Huang |
| E-mail(s) |
chengyhuang@hotmail.com
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| Organization name |
Shantou University Medical College
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| Street address |
22 Xinling Street
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| City |
Shantou |
| ZIP/Postal code |
515041 |
| Country |
China |
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| Platforms (1) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE212725 |
Transcriptional and epigenetic dysregulation impairs generation of proliferative neural stem and progenitor cells during brain aging |
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| Relations |
| BioProject |
PRJNA887809 |
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