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| Status |
Public on Oct 01, 2023 |
| Title |
Nanog mediates erasure of imprint-associated epigenetic marks via Prdm14 |
| Organism |
Mus musculus |
| Experiment type |
Methylation profiling by high throughput sequencing
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| Summary |
Nanog’s target Prdm14 is upregulated in 2iL-ESCs and leads to loss of Zfp57 and epigenetic marks from imprinting control regions.
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| |
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| Overall design |
Single cell bisulphite sequencing of primordial germ cells collected from Prdm14-null embryos at day 13.5 of gestation
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| Contributor(s) |
Costa Y, Bates LE, Lauzikaite E, Handford CE, Galvão A, Castillo-Fernandez J, Barrero M, Mallol A, Stockwell I, Maskalenka K, Leitch H, Dietmann S, Saitou M, Kelsey G, Payer B, Mohorianu I, Rebelo da Silva JC |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Oct 05, 2022 |
| Last update date |
Oct 02, 2023 |
| Contact name |
Laura Biggins |
| E-mail(s) |
laura.biggins@babraham.ac.uk
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| Organization name |
The Babraham Institute
|
| Department |
Bioinformatics
|
| Street address |
Babraham Research Campus
|
| City |
Cambridge |
| ZIP/Postal code |
CB22 3AT |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (89)
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| Relations |
| BioProject |
PRJNA887412 |
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