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Series GSE21478 Query DataSets for GSE21478
Status Public on Jun 10, 2010
Title The Genome Wide Structure of the Jewish People
Organism Homo sapiens
Experiment type Genome variation profiling by SNP array
SNP genotyping by SNP array
Summary Contemporary Jews comprise an aggregate of ethno-religious communities whose worldwide members identify with each other through various shared religious, historical, and cultural traditions1,2. Historical evidence suggests common origins in the Middle East, followed by migrations leading to the establishment of communities of Jews in Europe, Africa, and Asia - in what is termed the Jewish Diaspora3-5. This complex demographic history imposes special challenges in attempting to address the genetic structure of the Jewish people6. While many genetic studies have shed light on Jewish diseases and origins, including those focusing on uniparentally- and biparentally-inherited markers7-16, genome-wide patterns of variation across the vast geographic span of Jewish Diaspora communities and their respective neighbors have yet to be addressed. Here we use high-density bead arrays to genotype individuals from 14 Jewish Diaspora communities, and compare these patterns of genome-wide diversity with those from 69 Old World non-Jewish populations, of which 25 have not been previously reported. These samples were carefully chosen to provide comprehensive comparisons between Jewish and non-Jewish populations in the Diaspora, as well as with non-Jewish populations from the Middle East and North Africa. Principal component and structure-like analyses identify previously unrecognized genetic substructure within the Middle East. Most Jewish samples form a remarkably tight sub-cluster that overlies Druze and Cypriot samples, but not samples from other Levantine populations or paired Diaspora host populations. In contrast, Ethiopian Jews (Beta Israel) and Bene Israel Indian Jews cluster with neighbouring autochthonous populations in Ethiopia and western India, respectively; despite a clear paternal link between the Bene Israel and the Levant. These results cast light on the variegated genetic architecture of the Middle East, and trace the origins of most Jewish Diaspora communities to the Levant.
Overall design 466 samples are analysed on three different Illumina platforms.
Contributor(s) Villems R, Metspalu M, Behar DM
Citation(s) 20531471
Submission date Apr 22, 2010
Last update date Jul 17, 2015
Contact name Mait Metspalu
Phone +37283315
Organization name Estonian Biocentre
Street address Riia 23
City Tartu
ZIP/Postal code 51010
Country Estonia
Platforms (3)
GPL6987 Illumina HumanHap650Yv3 Genotyping BeadChip (HumanHap650Yv3_A)
GPL8887 Illumina Human610-Quad v1.0 BeadChip
GPL8888 Illumina Human660W-Quad v1.0 BeadChip
Samples (466)
GSM536493 Male Cochin Jews South Asia Indian_Jew_1 Human610-Quad v1.0
GSM536494 Male Cochin Jews South Asia Indian_Jew_2 Human610-Quad v1.0
GSM536495 Male Cochin Jews South Asia Indian_Jew_3 Human610-Quad v1.0
BioProject PRJNA126045

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE21478_610_j_Xraw_Yraw.txt.gz 2.9 Gb (ftp)(http) TXT
GSE21478_610_j_Xraw_Yraw_b.txt.gz 25.3 Mb (ftp)(http) TXT
GSE21478_610_matrix.txt.gz 3.9 Gb (ftp)(http) TXT
GSE21478_610_matrix_b.txt.gz 36.2 Mb (ftp)(http) TXT
GSE21478_650_j_Xraw_Yraw.txt.gz 34.7 Mb (ftp)(http) TXT
GSE21478_650_matrix.txt.gz 54.9 Mb (ftp)(http) TXT
GSE21478_660_j_Xraw_Yraw.txt.gz 661.1 Mb (ftp)(http) TXT
GSE21478_660_matrix.txt.gz 980.9 Mb (ftp)(http) TXT
GSE21478_RAW.tar 70.0 Mb (http)(custom) TAR
Raw data are available on Series record
Processed data included within Sample table
Processed data are available on Series record

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