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Series GSE214530 Query DataSets for GSE214530
Status Public on Sep 30, 2022
Title Time- and tissue-specific response of the mouse transcriptome after a short-term exposure to normoxia or intermittent hypoxia (IH)
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary To investigated the effects of early exposure to IH on tissue-specific transcriptome and biological processes, we evaluated differential gene expression of circadian rhythms and 24-hour mean expression in the lung, heart, liver, kidney, muscle, and cerebellum from mice after exposure to normoxic and IH conditions. The cardiopulmonary tissues were most affected by short-term exposure to IH in comparison with other organs.
 
Overall design Eight-week-old C57BL/6J mice were exposed to either normoxia or intermittent hypooxia (21-8% O2) for seven days before it was released into constant normoxic darkness for two days. Multiple tissues (liver, lung, kidney, muscle, heart, and cerebellum) were harvested on the second day of constant darkness for 24 hours with three-hour intervals to assess changes in their transcriptome.
Web link https://doi.org/10.1371/journal.pbio.3002139
 
Contributor(s) Koritala BS, Lee YY, Smith DF
Citation(s) 37252926
NIH grant(s)
Grant ID Grant title Affiliation Name
K08 HL148551 Circadian Clock Dysregulation in a Model of Obstructive Sleep Apnea CHILDREN'S HOSPITAL MEDICAL CENTER David F Smith
Submission date Sep 30, 2022
Last update date May 30, 2023
Contact name Bala S. C. Koritala
E-mail(s) bala.koritala@cchmc.org
Phone 8563977226
Organization name Cincinnati Children's Hospital Medical Center
Department Division of Pediatric Otolaryngology
Lab Koritala lab
Street address 3333 Burnet Avenue
City Cincinnati
State/province Ohio
ZIP/Postal code 45229
Country USA
 
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (288)
GSM6610567 C57BL/6J mouse, IH, cerebellum, replicate 1, time point 1:30 h [Cerebellum_IH_1:30_rep1]
GSM6610568 C57BL/6J mouse, normoxia, cerebellum, replicate 1, time point 1:30 h [Cerebellum_Norm_1:30_rep1]
GSM6610569 C57BL/6J mouse, IH, cerebellum, replicate 2, time point 1:30 h [Cerebellum_IH_1:30_rep2]
Relations
BioProject PRJNA885815
SRA SRP400444

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE214530_Cerebellum.intermittenthypoxia.gene.tpm.csv.gz 2.5 Mb (ftp)(http) CSV
GSE214530_Cerebellum.normoxia.gene.tpm.csv.gz 2.5 Mb (ftp)(http) CSV
GSE214530_Heart.intermittenthypoxia.gene.tpm.csv.gz 2.4 Mb (ftp)(http) CSV
GSE214530_Heart.normoxia.gene.tpm.csv.gz 2.7 Mb (ftp)(http) CSV
GSE214530_Kidney.intermittenthypoxia.gene.tpm.csv.gz 2.4 Mb (ftp)(http) CSV
GSE214530_Kidney.normoxia.gene.tpm.csv.gz 2.4 Mb (ftp)(http) CSV
GSE214530_Liver.intermittenthypoxia.gene.tpm.csv.gz 2.3 Mb (ftp)(http) CSV
GSE214530_Liver.normoxia.gene.tpm.csv.gz 2.3 Mb (ftp)(http) CSV
GSE214530_Lung.intermittenthypoxia.gene.tpm.csv.gz 2.7 Mb (ftp)(http) CSV
GSE214530_Lung.normoxia.gene.tpm.csv.gz 2.5 Mb (ftp)(http) CSV
GSE214530_Muscle.intermittenthypoxia.gene.tpm.csv.gz 2.5 Mb (ftp)(http) CSV
GSE214530_Muscle.normoxia.gene.tpm.csv.gz 2.5 Mb (ftp)(http) CSV
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