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| Status |
Public on May 31, 2023 |
| Title |
Enhanced STAT5a activation opposes Tox and rewires exhausted CD8 T cells towards a hybrid durable effector-like state during chronic stimulation |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
Expression profiling by high throughput sequencing
Other
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| Summary |
This SuperSeries is composed of the SubSeries listed below.
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| Overall design |
Refer to individual Series
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| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Sep 24, 2022 |
| Last update date |
Aug 31, 2023 |
| Contact name |
E JOHN WHERRY |
| Organization name |
University of Pennsylvania
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| Department |
Systems Pharmacology and Translational Therapeutics,Institute for Immunology
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| Street address |
421 Curie Blvd,354 BRB II/III
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| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19104 |
| Country |
USA |
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| Platforms (2) |
| GPL21626 |
NextSeq 550 (Mus musculus) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (62)
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| GSM6599257 |
postInfection, Teff1 |
| GSM6599258 |
postInfection, Teff2 |
| GSM6599259 |
postInfection, Teff3 |
| GSM6599260 |
postInfection, Teff4 |
| GSM6599261 |
postInfection, Empty1 |
| GSM6599262 |
postInfection, Empty2 |
| GSM6599263 |
postInfection, Empty3 |
| GSM6599264 |
postInfection, Empty4 |
| GSM6599265 |
postInfection, Stat5CA1 |
| GSM6599266 |
postInfection, Stat5CA2 |
| GSM6599267 |
postInfection, Stat5CA3 |
| GSM6599268 |
postInfection, Stat5CA4 |
| GSM6599269 |
postChallenge, Naive1 |
| GSM6599270 |
postChallenge, Naive2 |
| GSM6599271 |
postChallenge, Naive3 |
| GSM6599272 |
postChallenge, Memory1 |
| GSM6599273 |
postChallenge, Memory2 |
| GSM6599274 |
postChallenge, Memory3 |
| GSM6599275 |
postChallenge, NT1 |
| GSM6599276 |
postChallenge, NT2 |
| GSM6599277 |
postChallenge, NT3 |
| GSM6599278 |
postChallenge, T1 |
| GSM6599279 |
postChallenge, T2 |
| GSM6599280 |
postChallenge, T3 |
| GSM6599281 |
P14, Empty |
| GSM6599282 |
P14, Stat5CA |
| GSM6599283 |
P14, IL2Rb ortho |
| GSM6599284 |
wt, GEX |
| GSM6599285 |
ko, GEX |
| GSM6599286 |
wt, ADT |
| GSM6599287 |
ko, ADT |
| GSM7660943 |
IgG_Naive_R1 |
| GSM7660944 |
IgG_Naive_R2 |
| GSM7660945 |
IgG_ArmEmpty_R1 |
| GSM7660946 |
IgG_ArmEmpty_R2 |
| GSM7660947 |
IgG_ArmStat5CA_R1 |
| GSM7660948 |
IgG_Cl13Empty_R1 |
| GSM7660949 |
IgG_Cl13Empty_R2 |
| GSM7660950 |
IgG_Cl13Stat5CA_R1 |
| GSM7660951 |
IgG_Cl13Stat5CA_R2 |
| GSM7660952 |
Naïve_R1 |
| GSM7660953 |
Naïve_R2 |
| GSM7660954 |
ArmEmpty_R1 |
| GSM7660955 |
ArmEmpty_R2 |
| GSM7660956 |
ArmStat5CA_R1 |
| GSM7660957 |
Cl13Empty_R1 |
| GSM7660958 |
Cl13Empty_R2 |
| GSM7660959 |
Cl13Stat5CA_R1 |
| GSM7660960 |
Cl13Stat5CA_R2 |
| GSM7697887 |
EmptyLy108-1 |
| GSM7697888 |
EmptyLy108-2 |
| GSM7697889 |
EmptyLy108-3 |
| GSM7697890 |
EmptyLy108-4 |
| GSM7697891 |
EmptyTim3-2 |
| GSM7697892 |
EmptyTim3-3 |
| GSM7697893 |
EmptyTim3-4 |
| GSM7697894 |
Stat5CATim3-1 |
| GSM7697895 |
Stat5CATim3-2 |
| GSM7697896 |
Stat5CATim3-3 |
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| This SuperSeries is composed of the following SubSeries:
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| GSE214111 |
Enhanced STAT5a activation opposes Tox and rewires exhausted CD8 T cells towards a hybrid durable effector-like state during chronic stimulation [ATAC-postInfection] |
| GSE214112 |
Enhanced STAT5a activation opposes Tox and rewires exhausted CD8 T cells towards a hybrid durable effector-like state during chronic stimulation [ATAC-postChallenge] |
| GSE214113 |
Enhanced STAT5a activation opposes Tox and rewires exhausted CD8 T cells towards a hybrid durable effector-like state during chronic stimulation [scRNA-seq_PostInfection] |
| GSE214114 |
Enhanced STAT5a activation opposes Tox and rewires exhausted CD8 T cells towards a hybrid durable effector-like state during chronic stimulation [CITE-seq_PostInfection] |
| GSE238239 |
Stat5 antagonizes Tox and CD8 T cell exhaustion to foster a durable effector-like state during chronic antigen exposure |
| GSE240431 |
Enhanced STAT5a activation opposes Tox and rewires exhausted CD8 T cells towards a hybrid durable effector-like state during chronic stimulation [ATAC-Seq] |
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| Relations |
| BioProject |
PRJNA883967 |
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