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Series GSE21374 Query DataSets for GSE21374
Status Public on May 24, 2010
Title Expression data from human renal allograft biopsies
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Kidney transplants that develop dysfunction or proteinuria after one year post transplant are at considerable risk for progression to renal failure. Identifying the molecules associated with graft failure could potentially lead to interventions that would slow the progression of organ failure.
We analyzed the relationship between gene expression in late biopsies for cause in human kidney transplants and subsequent graft loss, and assessed the predictive value of gene expression. We evaluated the performance of these genes in an independent , and in a population of early biopsies that have a very low risk of subsequent graft failure.
 
Overall design All consenting renal transplant patients undergoing biopsies for cause as standard of care between 09/2004 and 10/2007 at the university of Alberta or between 11/2006 and 02/2007 at the University of Illinois were included in the analysis. In addition, biopsies obtained from Minnesota between 09/2006 and 09/2007 were used as an independent . In addition to the cores required for standard histopathology, we collected one core for gene expression studies. the relationship between gene expression in the biopsy and subsequent graft loss was analyzed.
 
Contributor(s) Einecke G, Reeve J, Halloran PF
Citation(s) 20501945
Submission date Apr 17, 2010
Last update date Mar 25, 2019
Contact name Jeff Reeve
E-mail(s) jreeve@ualberta.ca
Organization name University of Alberta
Lab Halloran
Street address 250 HMRC University of Alberta
City Edmonton
State/province Alberta
ZIP/Postal code T6G 2S2
Country Canada
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (282)
GSM533921 renal allograft biopsy, (U of A/Chicago) 100A4AGX7
GSM533922 renal allograft biopsy, (U of A/Chicago) 101A3AGX7
GSM533923 renal allograft biopsy, (U of A/Chicago) 103A3AGX7
Relations
BioProject PRJNA126085

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE21374_RAW.tar 1.3 Gb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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