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| Status |
Public on Sep 22, 2022 |
| Title |
Frequent low-dose THC in adolescence disrupts microglia homeostasis and disables response to microbial infection |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Adolescence is a time of experimentation with cannabis. We evaluated whether adolescent exposure to the drug's psychotropic consituent, delta-9-tetrahydrocannabidiol (THC), might persistently alter microglia function and brain immune responses to lipopolysaccaride administration.
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| Overall design |
We administered THC (5 mg/kg, i.p.) once daily from postnatal day 30-44 and examined the brain transcriptome in adult animals (PND70) under basal or lipopolysaccharide (LPS, 0.33 mg/kg)-stimulated conditions.
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| Contributor(s) |
Piomelli D, Jung K, Lee H, Squire E |
| Citation(s) |
35750512 |
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| Submission date |
Sep 19, 2022 |
| Last update date |
Sep 24, 2022 |
| Contact name |
Daniele Piomelli |
| E-mail(s) |
piomelli@uci.edu
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| Organization name |
University of California, Irvine
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| Street address |
837 Health Sciences Road
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| City |
Irvine |
| ZIP/Postal code |
92697 |
| Country |
USA |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (12)
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| GSM6592917 |
Brain, THC, Ctrl1 |
| GSM6592918 |
Brain, THC, Ctrl2 |
| GSM6592919 |
Brain, THC, Ctrl3 |
| GSM6592920 |
Brain, Veh, LPS1 |
| GSM6592921 |
Brain, Veh, LPS2 |
| GSM6592922 |
Brain, Veh, LPS3 |
| GSM6592923 |
Brain, THC, LPS1 |
| GSM6592924 |
Brain, THC, LPS2 |
| GSM6592925 |
Brain, THC, LPS3 |
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| Relations |
| BioProject |
PRJNA882132 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE213734_RAW.tar |
30.9 Mb |
(http)(custom) |
TAR (of XLSX) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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