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| Status |
Public on Jan 01, 2011 |
| Title |
Genome-wide empirical binding sites co-occupied by p53 and NF-kB in human cardiomyopathy |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
p53 and NF-kB are important transcription factors involved in the pathogenesis of cardiac hypertrophy and the progression to heart failure/dilatation. We report the genome-wide empirical binding sites co-occupied by the transcription factors in human dilated hearts. p53-NF-kB sequential chromatin immunoprecipitation and high-throughput sequencing were performed using tissues from control and diseased hearts. These data may facilitate the discovery of mechanisms by which transcription factors cooperate in close proximity or a multi-molecular complex at a cis-regulatory element to control gene expression.
Raw data (qseq format) files are available on the following FTP site:
ftp://ftp.ncbi.nlm.nih.gov/pub/geosup/Series/GSE21356
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| Overall design |
Examination of p53 and NF-kB transcription factor binding sites in 4 control and 4 diseased hearts (pooled) using ChIP-Seq.
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| Contributor(s) |
Choy M, Foo RS |
| Citation(s) |
20546595 |
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| Submission date |
Apr 15, 2010 |
| Last update date |
Dec 03, 2018 |
| Contact name |
Mun-Kit Choy |
| Organization name |
University of Cambridge
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| Department |
Division of Cardiovascular Medicine
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| Street address |
Box 110, Level 6, ACCI Building, Addenbrooke’s Hospital, Hills Road
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| City |
Cambridge |
| State/province |
Cambridgeshire |
| ZIP/Postal code |
CB2 2QQ |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL9115 |
Illumina Genome Analyzer II (Homo sapiens) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA126113 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE21356_RAW.tar |
1.6 Gb |
(http)(custom) |
TAR (of BED, TAR, TXT, WIG) |
| GSE21356_readme.txt |
1.8 Kb |
(ftp)(http) |
TXT |
| Processed data provided as supplementary file |
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