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| Status |
Public on Oct 24, 2022 |
| Title |
Krüppel-like factor 4 regulates the cytolytic effector function of exhausted CD8 T-cells [RNA-Seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To identify the role of KLF4 on exhausted CD8 T-cells, we retrovirally transduced Klf4 into OT-I CD8 T-cells on day1 of in vitro exhaustion model and repeatedly treated OVA peptide to induce exhaustion.
Then we analyzed the gene expression profiles of these transduced cells by RNA-sequencing.
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| |
|
| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for CD8 T-cells transduced with MigRI and Klf4
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| |
|
| Contributor(s) |
Seong R, Nah J |
| Citation(s) |
36427304 |
| |
| Submission date |
Sep 06, 2022 |
| Last update date |
Jan 04, 2023 |
| Contact name |
Jinwoo Nah |
| E-mail(s) |
wlsdnzii@gmail.com
|
| Phone |
01067621737
|
| Organization name |
Seoul National University
|
| Department |
Life science
|
| Lab |
Lab of Molecular Immunology
|
| Street address |
1, Gwanak-ro, Gwanak-gu, Seoul
|
| City |
Seoul |
| ZIP/Postal code |
08826 |
| Country |
South Korea |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE212806 |
Krüppel-like factor 4 regulates the cytolytic effector function of exhausted CD8 T-cells |
|
| Relations |
| BioProject |
PRJNA877359 |
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