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| Status |
Public on Aug 26, 2024 |
| Title |
Balancing the CKS1/CKS2 proteostasis axis is critical to maintain hematopoietic stem cell function |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Investigation of the roles of CKS1 and CKS2 in murine haematopoiesis.
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| Overall design |
Bulk RNA sequencing of LSK cells from WT, Cks1b-/- and Cks2-/- 8-week-old mice.
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| Contributor(s) |
Grey W, Llorian Sopena M |
| Citation(s) |
36874381 |
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| Submission date |
Sep 06, 2022 |
| Last update date |
Nov 28, 2024 |
| Contact name |
William Grey |
| E-mail(s) |
william.grey@york.ac.uk
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| Organization name |
Francis Crick Institute
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| Lab |
Haematopoietic Stem Cell Laboratory
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| Street address |
1 Midland Road
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| City |
London |
| ZIP/Postal code |
NW1 1AT |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (14)
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| GSM6552417 |
WT lineage marker negative, cKit positive, Sca1 positive bone marrow derived cells [WT_LSK_1] |
| GSM6552418 |
WT lineage marker negative, cKit positive, Sca1 positive bone marrow derived cells [WT_LSK_2] |
| GSM6552419 |
WT lineage marker negative, cKit positive, Sca1 positive bone marrow derived cells [WT_LSK_3] |
| GSM6552420 |
WT lineage marker negative, cKit positive, Sca1 positive bone marrow derived cells [WT_LSK_4] |
| GSM6552421 |
WT lineage marker negative, cKit positive, Sca1 positive bone marrow derived cells [WT_LSK_5] |
| GSM6552422 |
CKS1b knockout lineage marker negative, cKit positive, Sca1 positive bone marrow derived cells [Cks1KO_LSK_1] |
| GSM6552423 |
CKS1b knockout lineage marker negative, cKit positive, Sca1 positive bone marrow derived cells [Cks1KO_LSK_3] |
| GSM6552424 |
CKS1b knockout lineage marker negative, cKit positive, Sca1 positive bone marrow derived cells [Cks1KO_LSK_4] |
| GSM6552425 |
CKS1b knockout lineage marker negative, cKit positive, Sca1 positive bone marrow derived cells [Cks1KO_LSK_5] |
| GSM6552426 |
CKS2 knockout lineage marker negative, cKit positive, Sca1 positive bone marrow derived cells [Cks2KO_LSK_1] |
| GSM6552427 |
CKS2 knockout lineage marker negative, cKit positive, Sca1 positive bone marrow derived cells [Cks2KO_LSK_2] |
| GSM6552428 |
CKS2 knockout lineage marker negative, cKit positive, Sca1 positive bone marrow derived cells [Cks2KO_LSK_3] |
| GSM6552429 |
CKS2 knockout lineage marker negative, cKit positive, Sca1 positive bone marrow derived cells [Cks2KO_LSK_4] |
| GSM6552430 |
CKS2 knockout lineage marker negative, cKit positive, Sca1 positive bone marrow derived cells [Cks2KO_LSK_5] |
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| Relations |
| BioProject |
PRJNA877261 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE212789_normalised_data.txt.gz |
1.9 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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