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| Status |
Public on Jan 01, 2024 |
| Title |
Chronic oral administration of nicotine affects transcriptomic profiling in conditional Presenilin 1/2 knockout mice and wild type mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
we found that chronic oral (3 months) administration of nicotine had different effects on transcriptomic profiling in prefrontal forebrain cortex of wildtype (WT) and Presenilin 1/2 double knockout mice.
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| Overall design |
8-month-old Presenilin 1/2 double knockout mice (DKO) and the wildtype mice (WT) were exposed to nicotine by drinking water at the dose of 100 μg/ml (DKO-N and WT-N, respectively) or water (DKO-B and WT-B, respectively) ad libitum for 3 months, after the behavior tests, the prefrontal forebrain cortex of the four groups of mice were collected for RNA-seq.
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| Contributor(s) |
Meng B, Si Y |
| Citation(s) |
39936411 |
| |
| Submission date |
Aug 24, 2022 |
| Last update date |
Mar 17, 2025 |
| Contact name |
Bo Meng |
| E-mail(s) |
bmeng2019@gmail.com
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| Organization name |
East China Normal Univeristy
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| Street address |
3663 Zhongshan Rd(N.)
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| City |
Shanghai |
| ZIP/Postal code |
200062 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA873087 |
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