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| Status |
Public on Oct 05, 2022 |
| Title |
The role HOXA5 in extrahepatic cholangiocarcinoma (Methylation) |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
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| Summary |
Homeobox A5 (HOXA5) is a transcription factor in mammalian and can regulate cell differentiation, proliferation and apoptosis as well as tumorigenesis. However, little is known on whether and how HOXA5 can regulate the malignant behaviors of cholangiocarcinoma. The methylation levels of HOXA5 were evaluated by methylation microarray and bisulfite sequencing PCR. We found that hypermethylation in the HOXA5 promoter down-regulated HOXA5 expression in extrahepatic cholangiocarcinoma (ECCA) tissues, which was correlated with worse overall survival. HOXA5 over-expression significantly inhibited the proliferation and tumor growth.
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| Overall design |
A fresh extrahepatic cholangiocarcinoma cell sample (TFK-1) and a normal bile duct sample were used for methylation analysis and we found HOXA5 was hypermethylated in extrahepatic cholangiocarcinoma sample compared with normal control sample.
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| Contributor(s) |
Wang B, Chen Y |
| Citation(s) |
36167790 |
| |
| Submission date |
Aug 23, 2022 |
| Last update date |
Oct 06, 2022 |
| Contact name |
Fei Xiong |
| E-mail(s) |
sillcon2008@hotmail.com
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| Organization name |
Huazhong University of Science and Technology
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| Street address |
Jiefang Road No.1095
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| City |
Wuhan |
| State/province |
Hubei |
| ZIP/Postal code |
430074 |
| Country |
China |
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| Platforms (1) |
| GPL16062 |
NimbleGen Human DNA Methylation 385K Promoter Plus CpG Island Array [2006-11-02_HG18_CpG_Promo] |
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| Samples (2) |
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| This SubSeries is part of SuperSeries: |
| GSE211912 |
The role HOXA5 in extrahepatic cholangiocarcinoma |
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| Relations |
| BioProject |
PRJNA872545 |
