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| Status |
Public on Oct 13, 2023 |
| Title |
Inhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills tumours by inducing readthrough transcription |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Other
|
| Summary |
This SuperSeries is composed of the SubSeries listed below.
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| Overall design |
Refer to individual Series
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| Citation(s) |
37831776 |
| |
| Submission date |
Aug 17, 2022 |
| Last update date |
Nov 28, 2023 |
| Contact name |
Vladislav Kuzin |
| E-mail(s) |
vladislav.kuzin@ki.se
|
| Phone |
+46707428667
|
| Organization name |
Karolinska Institute
|
| Department |
Cell and Molecular Biology
|
| Lab |
Laura Baranello
|
| Street address |
Solnavägen 9
|
| City |
Solna |
| State/province |
Stockholm |
| ZIP/Postal code |
171 65 |
| Country |
Sweden |
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| Platforms (3) |
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| Samples (124)
|
| GSM6473044 |
TOP1 CAD 1hr SN38 rep 2 |
| GSM6473045 |
TOP1 CAD 1hr SN38+JQ1 rep 1 |
| GSM6473046 |
TOP1 CAD 1hr SN38+JQ1 rep 2 |
| GSM6473061 |
H3K27ac vehicle rep 1 |
| GSM6473062 |
H3K27ac vehicle rep 2 |
| GSM6473063 |
H3K27ac SN38 rep 1 |
| GSM6473064 |
H3K27ac SN38 rep 2 |
| GSM6473065 |
H3K27ac JQ1 rep 1 |
| GSM6473066 |
H3K27ac JQ1 rep 2 |
| GSM6473067 |
H3K27ac combo rep 1 |
| GSM6473068 |
H3K27ac combo rep 2 |
| GSM6473069 |
H3K36me3 vehicle rep 1 |
| GSM6473070 |
H3K36me3 vehicle rep 2 |
| GSM6473071 |
H3K36me3 SN38 rep 1 |
| GSM6473072 |
H3K36me3 SN38 rep 2 |
| GSM6473073 |
H3K36me3 JQ1 rep 1 |
| GSM6473074 |
H3K36me3 JQ1 rep 2 |
| GSM6473075 |
H3K36me3 combo rep 1 |
| GSM6473076 |
H3K36me3 combo rep 2 |
| GSM6473077 |
BRD4 vehicle rep 1 |
| GSM6473078 |
BRD4 vehicle rep 2 |
| GSM6473079 |
BRD4 SN38 rep 1 |
| GSM6473080 |
BRD4 SN38 rep 2 |
| GSM6473081 |
BRD4 JQ1 rep 1 |
| GSM6473082 |
BRD4 JQ1 rep 2 |
| GSM6473083 |
BRD4 combo rep 1 |
| GSM6473084 |
BRD4 combo rep 2 |
| GSM6473085 |
RNAPII-ser2P vehicle rep 1 |
| GSM6473086 |
RNAPII-ser2P vehicle rep 2 |
| GSM6473087 |
RNAPII-ser2P SN38 rep 1 |
| GSM6473088 |
RNAPII-ser2P SN38 rep 2 |
| GSM6473089 |
RNAPII-ser2P JQ1 rep 1 |
| GSM6473090 |
RNAPII-ser2P JQ1 rep 2 |
| GSM6473091 |
RNAPII-ser2P combo rep 1 |
| GSM6473092 |
RNAPII-ser2P combo rep 2 |
| GSM6473093 |
Cstf64 vehicle rep 1 |
| GSM6473094 |
Cstf64 vehicle rep 2 |
| GSM6473095 |
Cstf64 SN38 rep 1 |
| GSM6473096 |
Cstf64 SN38 rep 2 |
| GSM6473097 |
Cstf64 JQ1 rep 1 |
| GSM6473098 |
Cstf64 JQ1 rep 2 |
| GSM6473099 |
Cstf64 combo rep 1 |
| GSM6473100 |
Cstf64 combo rep 2 |
| GSM6473101 |
Input before IP, reference for peak calling |
| GSM6473102 |
panNEC, PDX, C1, 0 hours, rep 1 |
| GSM6473103 |
panNEC, PDX, C1, 4 hours, rep 1 |
| GSM6473104 |
panNEC, PDX, C1, 12 hours, rep 1 |
| GSM6473105 |
panNEC, PDX, C1, 24 hours, rep 1 |
| GSM6473106 |
panNEC, PDX, C2, 0 hours, rep 1 |
| GSM6473107 |
panNEC, PDX, C2, 4 hours, rep 1 |
| GSM6473108 |
panNEC, PDX, C2, 24 hours, rep 1 |
| GSM6473109 |
panNEC, PDX, C3, 0 hours, rep 1 |
| GSM6473110 |
panNEC, PDX, C1, 4 hours, rep 2 |
| GSM6473111 |
panNEC, PDX, C2, 0 hours, rep 2 |
| GSM6473112 |
panNEC, PDX, C2, 24 hours, rep 2 |
| GSM6473113 |
panNEC, PDX, C3, 0 hours, rep 2 |
| GSM6473114 |
PDAC, PDX, C1, 4 hours, rep 1 |
| GSM6473115 |
PDAC, PDX, C1, 12 hours, rep 1 |
| GSM6473116 |
PDAC, PDX, C1, 24 hours, rep 1 |
| GSM6473117 |
PDAC, PDX, C1, 0 hours, rep 1 |
| GSM6473118 |
PDAC, PDX, C2, 0 hours, rep 1 |
| GSM6473119 |
PDAC, PDX, C2, 4 hours, rep 1 |
| GSM6473120 |
PDAC, PDX, C2, 12 hours, rep 1 |
| GSM6473121 |
PDAC, PDX, C2, 24 hours, rep 1 |
| GSM6473122 |
PDAC, PDX, C3, 0 hours, rep 1 |
| GSM6473123 |
PDAC, PDX, C3, 4 hours, rep 1 |
| GSM6473124 |
PDAC, PDX, C2, 0 hours, rep 2 |
| GSM6473125 |
PDAC, PDX, C1, 4 hours, rep 2 |
| GSM6473126 |
PDAC, PDX, C1, 12 hours, rep 2 |
| GSM6473127 |
PDAC, PDX, C1, 24 hours, rep 2 |
| GSM6473128 |
PDAC, PDX, C2, 12 hours, rep 2 |
| GSM6473129 |
panNEC, PDX, JQ1 + Irinotecan, 5 days, 4 hours, rep 1 |
| GSM6473130 |
panNEC, PDX, JQ1 + Irinotecan, 5 days, 4 hours, rep 2 |
| GSM6473131 |
panNEC, PDX, Irinotecan, 5 days, 4 hours, rep 1 |
| GSM6473132 |
panNEC, PDX, Irinotecan, 5 days, 4 hours, rep 2 |
| GSM6473133 |
panNEC, PDX, JQ1, 5 days, 4 hours, rep 1 |
| GSM6473134 |
panNEC, PDX, JQ1, 5 days, 4 hours, rep 2 |
| GSM6473135 |
panNEC, PDX, vehicle, 5 days, 4 hours, rep 1 |
| GSM6473136 |
panNEC, PDX, vehicle, 5 days, 4 hours, rep 2 |
| GSM6473137 |
PDAC, DMSO, 4 hours, rep 1 |
| GSM6473138 |
PDAC, DMSO, 4 hours, rep 2 |
| GSM6473139 |
PDAC, DMSO, 4 hours, rep 3 |
| GSM6473140 |
PDAC, SN38, 4 hours, rep 1 |
| GSM6473141 |
PDAC, SN38, 4 hours, rep 2 |
| GSM6473142 |
PDAC, SN38, 4 hours, rep 3 |
| GSM6473143 |
PDAC, JQ1, 4 hours, rep 1 |
| GSM6473144 |
PDAC, JQ1, 4 hours, rep 2 |
| GSM6473145 |
PDAC, JQ1, 4 hours, rep 3 |
| GSM6473146 |
PDAC, SN38 + JQ1, 4 hours, rep 1 |
| GSM6473147 |
PDAC, SN38 + JQ1, 4 hours, rep 2 |
| GSM6473148 |
PDAC, SN38 + JQ1, 4 hours, rep 3 |
| GSM6473149 |
PDAC, DMSO, 4 hours, early S-phase, rep 1 |
| GSM6473150 |
PDAC, SN38, 4 hours, early S-phase, rep 1 |
| GSM6473151 |
PDAC, JQ1, 4 hours, early S-phase, rep 1 |
| GSM6473152 |
PDAC, SN38+JQ1, 4 hours, early S-phase, rep 1 |
| GSM6473153 |
PDAC, DMSO, 4 hours, early S-phase, rep 2 |
| GSM6473154 |
PDAC, SN38, 4 hours, early S-phase, rep 2 |
| GSM6473155 |
PDAC, JQ1, 4 hours, early S-phase, rep 2 |
| GSM6473156 |
PDAC, SN38+JQ1, 4 hours, early S-phase, rep 2 |
| GSM6473157 |
PDAC, DMSO, 4 hours, late S-phase, rep 1 |
| GSM6473158 |
PDAC, SN38, 4 hours, late S-phase, rep 1 |
| GSM6473159 |
PDAC, JQ1, 4 hours, late S-phase, rep 1 |
| GSM6473160 |
PDAC, SN38+JQ1, 4 hours, late S-phase, rep 1 |
| GSM6473161 |
PDAC, DMSO, 4 hours, late S-phase, rep 2 |
| GSM6473162 |
PDAC, SN38, 4 hours, late S-phase, rep 2 |
| GSM6473163 |
PDAC, JQ1, 4 hours, late S-phase, rep 2 |
| GSM6473164 |
PDAC, SN38+JQ1, 4 hours, late S-phase, rep 2 |
| GSM7466306 |
RNAPII vehicle rep 1 |
| GSM7466307 |
RNAPII vehicle rep 2 |
| GSM7466308 |
RNAPII SN38 rep 1 |
| GSM7466309 |
RNAPII SN38 rep 2 |
| GSM7466310 |
RNAPII JQ1 rep 1 |
| GSM7466311 |
RNAPII JQ1 rep 2 |
| GSM7466312 |
RNAPII combo rep 1 |
| GSM7466313 |
RNAPII combo rep 2 |
| GSM7466314 |
TOP1 vehicle rep 1 |
| GSM7466315 |
TOP1 vehicle rep 2 |
| GSM7466316 |
TOP1 SN38 rep 1 |
| GSM7466317 |
TOP1 SN38 rep 2 |
| GSM7466320 |
TOP1 combo rep 1 |
| GSM7466321 |
TOP1 combo rep 2 |
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| This SuperSeries is composed of the following SubSeries:
|
| GSE211465 |
Inhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills tumours by inducing readthrough transcription [CAD-seq] |
| GSE211467 |
Inhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills tumours by inducing readthrough transcription [ChIP-seq] |
| GSE211468 |
Inhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills tumours by inducing readthrough transcription [RNA-seq] |
| GSE211469 |
Inhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills tumours by inducing readthrough transcription [SLAM-seq] |
| GSE211470 |
Inhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills tumours by inducing readthrough transcription [Repli-seq] |
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| Relations |
| BioProject |
PRJNA870461 |
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