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Series GSE21082 Query DataSets for GSE21082
Status Public on Oct 22, 2021
Title Glutaminyl cyclase (QC) activity affects gene expression in macrophages during inflammation
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Glutaminyl cyclase (QC) activity in macrophage cells is correlated with the gene expression of MCP-2 and QC-catalyzed N-terminal pGlu formation of MCPs is required for macrophage migration and provide new insights into the role of QC in the inflammation process.
 
Overall design In the study presented here, we found that 3,770 genes exhibited different expression level (> 1.7 folds) in response to the treatment of LPS, and that 4,124 genes showed different expression in response to the treatments of PBD150 inhibitor and LPS. The overlap between both conditions contained 602 genes, we identified 10 genes whose expression levels are significantly correlated with the pretreatment of PBD150 inhibitor.
27 samples: untreated control, LPS only treatment, and LPS and PBD150 QC inhibitor treatment
 
Contributor(s) Chen Y, Wang AH
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Mar 26, 2010
Last update date Oct 22, 2021
Contact name Chen Yi Ling
Organization name Academia Sinica
Department Institute of Biological Chemistry
Lab 501
Street address 128 Academia Road, Section 2
City Taipei
ZIP/Postal code 11529
Country Taiwan
 
Platforms (1)
GPL6254 Phalanx Human OneArray
Samples (27)
GSM527031 Untreated biol rep 1 tech rep 1
GSM527032 Untreated biol rep 1 tech rep 2
GSM527033 Untreated biol rep 1 tech rep 3
Relations
BioProject PRJNA126721

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE21082_RAW.tar 71.6 Mb (http)(custom) TAR (of GPR)
Processed data included within Sample table
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