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Series GSE21007 Query DataSets for GSE21007
Status Public on Sep 01, 2010
Title Whole-genome gene expression profiling of dorsal root ganglion neurons after nerve damage
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary We generated whole-genome gene expression profiles of dorsal root ganglion (DRG) neurons following nerve damage. DRG neurons extend one peripheral axon into the spinal nerve and one central axon into the dorsal root. The peripheral axon regenerates vigorously, while in contrast the central axon has little regenerative capacity. For this study, two groups of animals were subjected either to sciatic nerve (SN) or dorsal root (DR) crush, and at 12, 24, 72 hours and 7 days after the crush, lumbar DRGs L4, L5 and L6 were dissected and total RNA was extracted.
 
Overall design For each time point after lesion, three biological replicate RNA samples were hybridized together with the common reference sample consisting of labeld RNA pooled from three unlesioned animals.
 
Contributor(s) MacGillavry HD, Geeven G, Eggers R, Verhaagen J, Smit AB, de Gunst MC, van Kesteren RE
Citation(s) 21422075
Submission date Mar 22, 2010
Last update date Apr 06, 2012
Contact name Harold D MacGillavry
E-mail hmacgillavry@gmail.com
Organization name Vrije Universiteit
Department Center for neurogenomics and cognitive research
Lab Molecular and cellular neurobiology
Street address De Boelelaan 1087
City Amsterdam
ZIP/Postal code 1081HV
Country Netherlands
 
Platforms (1)
GPL7289 Agilent-013162 Whole Rat Genome Microarray G4131A (Probe Name version)
Samples (24)
GSM524914 DRG_SN_12h_rep1
GSM524915 DRG_SN_12h_rep2
GSM524916 DRG_SN_12h_rep3
Relations
BioProject PRJNA125791

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE21007_RAW.tar 276.6 Mb (http)(custom) TAR (of TXT)
Raw data provided as supplementary file
Processed data included within Sample table

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