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| Status |
Public on Oct 27, 2023 |
| Title |
Transcriptional and epigenetic reprogramming mediated by chronic IL1β exposure drives self-renewal ability and myeloid priming in TET2 deficient stem and progenitor cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
Methylation profiling by high throughput sequencing
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| Summary |
This SuperSeries is composed of the SubSeries listed below.
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| Overall design |
Refer to individual Series
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| Citation(s) |
38062031 |
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| Submission date |
Jul 29, 2022 |
| Last update date |
Dec 14, 2023 |
| Contact name |
Anupriya Agarwal |
| Organization name |
Oregon Health & Science Univ
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| Department |
OHSU Knight Cancer Institute/ CEDAR
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| Lab |
Agarwal lab
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| Street address |
2730 S Moody Ave
|
| City |
Portland |
| State/province |
OR |
| ZIP/Postal code |
97201 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (64)
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| GSM6412431 |
Bone Marrow, Tet2-WT, vehicle, replicate 1 & 2, scRNAseq |
| GSM6412432 |
Bone Marrow, Tet2-WT, vehicle, replicate 1 & 2, HTO cDNA |
| GSM6412433 |
Bone Marrow, Tet2-WT, vehicle, replicate 3 & 4, scRNAseq |
| GSM6412434 |
Bone Marrow, Tet2-WT, vehicle, replicate 3 & 4, HTO cDNA |
| GSM6412435 |
Bone Marrow, Tet2-WT, IL-1ß, replicate 1 & 2, scRNAseq |
| GSM6412436 |
Bone Marrow, Tet2-WT, IL-1ß, replicate 1 & 2, HTO cDNA |
| GSM6412437 |
Bone Marrow, Tet2-WT, IL-1ß, replicate 3 & 4, scRNAseq |
| GSM6412438 |
Bone Marrow, Tet2-WT, IL-1ß, replicate 3 & 4, HTO cDNA |
| GSM6412439 |
Bone Marrow, Tet2-KO, vehicle, replicate 1 & 2, scRNAseq |
| GSM6412440 |
Bone Marrow, Tet2-KO, vehicle, replicate 1 & 2, HTO cDNA |
| GSM6412441 |
Bone Marrow, Tet2-KO, vehicle, replicate 3 & 4, scRNAseq |
| GSM6412442 |
Bone Marrow, Tet2-KO, vehicle, replicate 3 & 4, HTO cDNA |
| GSM6412443 |
Bone Marrow, Tet2-KO, IL-1ß, replicate 1 & 2, scRNAseq |
| GSM6412444 |
Bone Marrow, Tet2-KO, IL-1ß, replicate 1 & 2, HTO cDNA |
| GSM6412445 |
Bone Marrow, Tet2-KO, IL-1ß, replicate 3 & 4, scRNAseq |
| GSM6412446 |
Bone Marrow, Tet2-KO, IL-1ß, replicate 3 & 4, HTO cDNA |
| GSM6415369 |
Bone Marrow (Lin-, Sca1+, cKit+), Tet2-WT, vehicle, replicate 1 |
| GSM6415370 |
Bone Marrow (Lin-, Sca1+, cKit+), Tet2-WT, vehicle, replicate 2 |
| GSM6415371 |
Bone Marrow (Lin-, Sca1+, cKit+), Tet2-WT, vehicle, replicate 3 |
| GSM6415372 |
Bone Marrow (Lin-, Sca1+, cKit+), Tet2-WT, vehicle, replicate 4 |
| GSM6415373 |
Bone Marrow (Lin-, Sca1+, cKit+), Tet2-WT, IL-1ß, replicate 1 |
| GSM6415374 |
Bone Marrow (Lin-, Sca1+, cKit+), Tet2-WT, IL-1ß, replicate 2 |
| GSM6415375 |
Bone Marrow (Lin-, Sca1+, cKit+), Tet2-WT, IL-1ß, replicate 3 |
| GSM6415376 |
Bone Marrow (Lin-, Sca1+, cKit+), Tet2-WT, IL-1ß, replicate 4 |
| GSM6415377 |
Bone Marrow (Lin-, Sca1+, cKit+), Tet2-KO, vehicle, replicate 1 |
| GSM6415378 |
Bone Marrow (Lin-, Sca1+, cKit+), Tet2-KO, vehicle, replicate 2 |
| GSM6415379 |
Bone Marrow (Lin-, Sca1+, cKit+), Tet2-KO, vehicle, replicate 3 |
| GSM6415380 |
Bone Marrow (Lin-, Sca1+, cKit+), Tet2-KO, vehicle, replicate 4 |
| GSM6415381 |
Bone Marrow (Lin-, Sca1+, cKit+), Tet2-KO, IL-1ß, replicate 1 |
| GSM6415382 |
Bone Marrow (Lin-, Sca1+, cKit+), Tet2-KO, IL-1ß, replicate 2 |
| GSM6415383 |
Bone Marrow (Lin-, Sca1+, cKit+), Tet2-KO, IL-1ß, replicate 3 |
| GSM6415384 |
Bone Marrow (Lin-, Sca1+, cKit+), Tet2-KO, IL-1ß, replicate 4 |
| GSM6415385 |
Bone Marrow, (Lin- Sca1- ckit+ CD34+ Fc Gamma-), Tet2-WT, vehicle, replicate 1 |
| GSM6415386 |
Bone Marrow, (Lin- Sca1- ckit+ CD34+ Fc Gamma-), Tet2-WT, vehicle, replicate 2 |
| GSM6415387 |
Bone Marrow, (Lin- Sca1- ckit+ CD34+ Fc Gamma-), Tet2-WT, vehicle, replicate 3 |
| GSM6415388 |
Bone Marrow, (Lin- Sca1- ckit+ CD34+ Fc Gamma-), Tet2-WT, vehicle, replicate 4 |
| GSM6415389 |
Bone Marrow, (Lin- Sca1- ckit+ CD34+ Fc Gamma-), Tet2-WT, IL-1ß, replicate 1 |
| GSM6415390 |
Bone Marrow, (Lin- Sca1- ckit+ CD34+ Fc Gamma-), Tet2-WT, IL-1ß, replicate 2 |
| GSM6415391 |
Bone Marrow, (Lin- Sca1- ckit+ CD34+ Fc Gamma-), Tet2-WT, IL-1ß, replicate 3 |
| GSM6415392 |
Bone Marrow, (Lin- Sca1- ckit+ CD34+ Fc Gamma-), Tet2-WT, IL-1ß, replicate 4 |
| GSM6415393 |
Bone Marrow, (Lin- Sca1- ckit+ CD34+ Fc Gamma-), Tet2-KO, vehicle, replicate 1 |
| GSM6415394 |
Bone Marrow, (Lin- Sca1- ckit+ CD34+ Fc Gamma-), Tet2-KO, vehicle, replicate 2 |
| GSM6415395 |
Bone Marrow, (Lin- Sca1- ckit+ CD34+ Fc Gamma-), Tet2-KO, vehicle, replicate 3 |
| GSM6415396 |
Bone Marrow, (Lin- Sca1- ckit+ CD34+ Fc Gamma-), Tet2-KO, vehicle, replicate 4 |
| GSM6415397 |
Bone Marrow, (Lin- Sca1- ckit+ CD34+ Fc Gamma-), Tet2-KO, IL-1ß, replicate 1 |
| GSM6415398 |
Bone Marrow, (Lin- Sca1- ckit+ CD34+ Fc Gamma-), Tet2-KO, IL-1ß, replicate 2 |
| GSM6415399 |
Bone Marrow, (Lin- Sca1- ckit+ CD34+ Fc Gamma-), Tet2-KO, IL-1ß, replicate 3 |
| GSM6415400 |
Bone Marrow, (Lin- Sca1- ckit+ CD34+ Fc Gamma-), Tet2-KO, IL-1ß, replicate 4 |
| GSM6415401 |
Bone Marrow (Lin-, Sca1-, ckit+, CD34+, Fc Gamma+), Tet2-WT, vehicle, replicate 1 |
| GSM6415402 |
Bone Marrow (Lin-, Sca1-, ckit+, CD34+, Fc Gamma+), Tet2-WT, vehicle, replicate 2 |
| GSM6415403 |
Bone Marrow (Lin-, Sca1-, ckit+, CD34+, Fc Gamma+), Tet2-WT, vehicle, replicate 3 |
| GSM6415404 |
Bone Marrow (Lin-, Sca1-, ckit+, CD34+, Fc Gamma+), Tet2-WT, vehicle, replicate 4 |
| GSM6415405 |
Bone Marrow (Lin-, Sca1-, ckit+, CD34+, Fc Gamma+), Tet2-WT, IL-1ß, replicate 1 |
| GSM6415406 |
Bone Marrow (Lin-, Sca1-, ckit+, CD34+, Fc Gamma+), Tet2-WT, IL-1ß, replicate 2 |
| GSM6415407 |
Bone Marrow (Lin-, Sca1-, ckit+, CD34+, Fc Gamma+), Tet2-WT, IL-1ß, replicate 3 |
| GSM6415408 |
Bone Marrow (Lin-, Sca1-, ckit+, CD34+, Fc Gamma+), Tet2-WT, IL-1ß, replicate 4 |
| GSM6415409 |
Bone Marrow (Lin-, Sca1-, ckit+, CD34+, Fc Gamma+), Tet2-KO, vehicle, replicate 1 |
| GSM6415410 |
Bone Marrow (Lin-, Sca1-, ckit+, CD34+, Fc Gamma+), Tet2-KO, vehicle, replicate 2 |
| GSM6415411 |
Bone Marrow (Lin-, Sca1-, ckit+, CD34+, Fc Gamma+), Tet2-KO, vehicle, replicate 3 |
| GSM6415412 |
Bone Marrow (Lin-, Sca1-, ckit+, CD34+, Fc Gamma+), Tet2-KO, vehicle, replicate 4 |
| GSM6415413 |
Bone Marrow (Lin-, Sca1-, ckit+, CD34+, Fc Gamma+), Tet2-KO, IL-1ß, replicate 1 |
| GSM6415414 |
Bone Marrow (Lin-, Sca1-, ckit+, CD34+, Fc Gamma+), Tet2-KO, IL-1ß, replicate 2 |
| GSM6415415 |
Bone Marrow (Lin-, Sca1-, ckit+, CD34+, Fc Gamma+), Tet2-KO, IL-1ß, replicate 3 |
| GSM6415416 |
Bone Marrow (Lin-, Sca1-, ckit+, CD34+, Fc Gamma+), Tet2-KO, IL-1ß, replicate 4 |
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| This SuperSeries is composed of the following SubSeries: |
| GSE209994 |
Transcriptional and epigenetic reprogramming mediated by chronic IL1β exposure drives self-renewal ability and myeloid priming in TET2 deficient stem and progenitor cells [10x_scRNAseq] |
| GSE210025 |
Transcriptional and epigenetic reprogramming mediated by chronic IL1β exposure drives self-renewal ability and myeloid priming in TET2 deficient stem and progenitor cells [Bisulfite-Seq] |
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| Relations |
| BioProject |
PRJNA863465 |
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