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Series GSE20987 Query DataSets for GSE20987
Status Public on May 10, 2010
Title Gene expression data of BCR-ABL1 transformed B cell precursors from BCL6 wild-type and BCL6 knockout mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary To elucidate the mechanism of BCL6-mediated pre-B cell survival signaling, we investigated the gene expression pattern in BCR-ABL1-transformed BCL6+/+ and BCL6-/- B cell precursors. Pharmacological inhibition of BCR-ABL1 was performed with the BCR-ABL1 kinase inhibitor STI571 (Imatinib).
 
Overall design BCR-ABL1 transformed B cell precursors of BCL6 wildtype and BCL6 knockout mice were either treated with 10µM STI571 (Imatinib) for 16 hours or cultured in absence of STI571. Three samples for each condition were processed.
 
Contributor(s) Duy C, Yu JJ, Nahar R, Swaminathan S, Kweon S, Polo JM, Valls E, Klemm L, Shojaee S, Cerchietti L, Schuh W, Jäck H, Hurtz C, Ramezani-Rad P, Herzog S, Jumaa H, Koeffler PH, de Alborán IM, Melnick AM, Ye HB, Müschen M
Citation(s) 20498019, 21593872, 21911423, 24821775, 23852341
Submission date Mar 20, 2010
Last update date Feb 11, 2019
Contact name Markus Müschen
E-mail mmuschen@chla.usc.edu
Phone + 1 323 361 5592
Fax +1 323 361 1516
URL http://www.lymphocytes.de/
Organization name University of Southern California
Department Childrens Hospital Los Angeles
Lab Müschen Lab
Street address 4650 Sunset Blvd
City Los Angeles
State/province CA
ZIP/Postal code 90027
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (12)
GSM523989 Bcl6 +/+ BCR-ABL1-transformed B cell precursors - untreated 1
GSM523990 Bcl6 +/+ BCR-ABL1-transformed B cell precursors - untreated 2
GSM523991 Bcl6 +/+ BCR-ABL1-transformed B cell precursors - untreated 3
Relations
BioProject PRJNA124499

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Supplementary file Size Download File type/resource
GSE20987_RAW.tar 41.4 Mb (http)(custom) TAR (of CEL)
SRA Run SelectorHelp
Raw data provided as supplementary file
Processed data included within Sample table

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