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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Feb 02, 2024 |
| Title |
Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis II |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We study the effect of Treg cell-derived Areg on hepatic stellate cells. Here we look at the transcriptional effect of Areg on hepatic stellate cells in vitro.
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| Overall design |
Quiescent hepatic stellate cells were isolated and cultured for 5 hours, then stimulated with recombinant mouse Areg (500 ng/mL) for 4 hours in starving media.
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| Contributor(s) |
Arpaia N, Savage TM, Forton KT, de los Santos K, Rouanne M, Alsina AO, Cavero R, Li F, Haeusler RA, Adam J, Schwabe RF |
| Citation(s) |
38309273 |
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| Submission date |
Jul 20, 2022 |
| Last update date |
May 03, 2024 |
| Contact name |
Nicholas Arpaia |
| E-mail(s) |
na2697@cumc.columbia.edu
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| Organization name |
Columbia University
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| Department |
Microbiology & Immunology
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| Street address |
701 West 168th Street
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| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10032 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (10)
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| GSM6364796 |
Hepatic stellate cells, control, sample 1 |
| GSM6364797 |
Hepatic stellate cells, control, sample 2 |
| GSM6364798 |
Hepatic stellate cells, control, sample 3 |
| GSM6364799 |
Hepatic stellate cells, control, sample 4 |
| GSM6364800 |
Hepatic stellate cells, control, sample 5 |
| GSM6364801 |
Hepatic stellate cells, Areg, sample 1 |
| GSM6364802 |
Hepatic stellate cells, Areg, sample 2 |
| GSM6364803 |
Hepatic stellate cells, Areg, sample 3 |
| GSM6364804 |
Hepatic stellate cells, Areg, sample 4 |
| GSM6364805 |
Hepatic stellate cells, Areg, sample 5 |
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| This SubSeries is part of SuperSeries: |
| GSE208706 |
Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis |
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| Relations |
| BioProject |
PRJNA860637 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE208705_RAW.tar |
15.9 Mb |
(http)(custom) |
TAR (of TSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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