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| Status |
Public on Feb 02, 2024 |
| Title |
Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis I |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We study the effect of Treg cell-derived Areg in chronic liver injury. Here we look at the transcriptional changes of Treg cells in fibrosis compared to control and conventional T cells in vivo.
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| Overall design |
Treg (TCRb+CD4+Foxp3+) and Tconv (TCRb+CD4+Foxp3-) cells were sorted from liver and spleen of Foxp3GFP mice, either control or CCl4 treated mice.
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| Contributor(s) |
Arpaia N, Savage TM, Forton KT, de los Santos K, Rouanne M, Alsina AO, Cavero R, Li F, Haeusler RA, Adam J, Schwabe RF |
| Citation(s) |
38309273 |
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| Submission date |
Jul 20, 2022 |
| Last update date |
May 03, 2024 |
| Contact name |
Nicholas Arpaia |
| E-mail(s) |
na2697@cumc.columbia.edu
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| Organization name |
Columbia University
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| Department |
Microbiology & Immunology
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| Street address |
701 West 168th Street
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| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10032 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (32)
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| GSM6357572 |
Liver Treg cells, CCl4, sample 1 |
| GSM6357574 |
Liver Treg cells, CCl4, sample 2 |
| GSM6357575 |
Liver Treg cells, CCl4, sample 3 |
| GSM6357577 |
Liver Treg cells, CCl4, sample 4 |
| GSM6357578 |
Liver Treg cells, CCl4, sample 5 |
| GSM6357579 |
Liver Tconv cells, control, sample 1 |
| GSM6357581 |
Liver Tconv cells, control, sample 2 |
| GSM6357582 |
Liver Tconv cells, control, sample 3 |
| GSM6357583 |
Liver Tconv cells, CCl4, sample 1 |
| GSM6357585 |
Liver Tconv cells, CCl4, sample 2 |
| GSM6357586 |
Liver Tconv cells, CCl4, sample 3 |
| GSM6357588 |
Liver Tconv cells, CCl4, sample 4 |
| GSM6357589 |
Liver Tconv cells, CCl4, sample 5 |
| GSM6357590 |
Spleen Treg cells, control, sample 1 |
| GSM6357592 |
Spleen Treg cells, control, sample 2 |
| GSM6357593 |
Spleen Treg cells, control, sample 3 |
| GSM6357595 |
Spleen Treg cells, CCl4, sample 1 |
| GSM6357596 |
Spleen Treg cells, CCl4, sample 2 |
| GSM6357597 |
Spleen Treg cells, CCl4, sample 3 |
| GSM6357599 |
Spleen Treg cells, CCl4, sample 4 |
| GSM6357600 |
Spleen Treg cells, CCl4, sample 5 |
| GSM6357602 |
Spleen Tconv cells, control, sample 1 |
| GSM6357603 |
Spleen Tconv cells, control, sample 2 |
| GSM6357604 |
Spleen Tconv cells, control, sample 3 |
| GSM6357606 |
Spleen Tconv cells, CCl4, sample 1 |
| GSM6357607 |
Spleen Tconv cells, CCl4, sample 2 |
| GSM6357608 |
Spleen Tconv cells, CCl4, sample 3 |
| GSM6357610 |
Spleen Tconv cells, CCl4, sample 4 |
| GSM6357611 |
Spleen Tconv cells, CCl4, sample 5 |
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| This SubSeries is part of SuperSeries: |
| GSE208706 |
Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis |
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| Relations |
| BioProject |
PRJNA860529 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE208641_RAW.tar |
52.7 Mb |
(http)(custom) |
TAR (of TSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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