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| Status |
Public on Jul 23, 2022 |
| Title |
Single-cell transcriptomic data in the spinal cord of Taiwanese type I SMA mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Although spinal muscular atrophy (SMA) is a motor neuron disease caused by the loss of survival of motor neuron protein, there is growing evidence that non-neuronal cells play important roles in SMA pathogenesis. However, transcriptome alterations occurring at the single-cell level in SMA spinal cord remain unknown, preventing us from fully comprehending the role of specific cells. Here, we performed single-cell RNA sequencing of the spinal cord of a severe SMA mouse model, and identified ten cell types as well as their differentially expressed genes.
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| Overall design |
Single-cell sequencing of spinal cords of postnatal day 4 SMA mice (mSmn-/-, hSMN22tg/0), heterozygous mice (mSmn+/-, hSMN22tg/0) as controls.
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| Contributor(s) |
Sun J, Wu L, Xing L |
| Citation(s) |
36074806 |
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| Submission date |
Jul 20, 2022 |
| Last update date |
Nov 03, 2022 |
| Contact name |
junjie sun |
| E-mail(s) |
jjsun@ntu.edu.cn
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| Phone |
+86 515506660626
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| Organization name |
nantong university
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| Street address |
19 Qixiu Road
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| City |
nantong |
| State/province |
jiangsu province |
| ZIP/Postal code |
226001 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA860370 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE208629_RAW.tar |
238.8 Mb |
(http)(custom) |
TAR (of MTX, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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